Abnormal Intrinsic Functional Hubs in Severe Male Obstructive Sleep Apnea: Evidence from a Voxel-Wise Degree Centrality Analysis

Autor: Si Nie, De-Chang Peng, Wei Zhang, Hai-Jun Li, Xianjun Zeng, Yi Shao, Lan Li, Cheng-Long Ye, Li-Ting Chen, Honghan Gong
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Critical Care and Emergency Medicine
Pulmonology
Physiology
Apnea
Hippocampus
lcsh:Medicine
Diagnostic Radiology
0302 clinical medicine
Cortex (anatomy)
Medicine and Health Sciences
Centrality
Brain Damage
lcsh:Science
Trauma Medicine
Cerebral Cortex
Cognitive Impairment
Sleep Apnea
Obstructive
Multidisciplinary
Cognitive Neurology
Radiology and Imaging
05 social sciences
Brain
Middle Aged
Magnetic Resonance Imaging
Frontal Lobe
medicine.anatomical_structure
Frontal lobe
Neurology
Cardiology
Anatomy
Network Analysis
Research Article
Adult
medicine.medical_specialty
Computer and Information Sciences
Sleep Apnea
Lentiform nucleus
Neural Networks
Imaging Techniques
Cognitive Neuroscience
Polysomnography
Research and Analysis Methods
050105 experimental psychology
03 medical and health sciences
Inferior temporal gyrus
Diagnostic Medicine
Internal medicine
medicine
Humans
0501 psychology and cognitive sciences
business.industry
lcsh:R
Biology and Life Sciences
Inferior parietal lobule
Emotional lateralization
Posterior cingulate
Cognitive Science
lcsh:Q
Nerve Net
business
Physiological Processes
Sleep
Sleep Disorders
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 11, Iss 10, p e0164031 (2016)
PLoS ONE
ISSN: 1932-6203
Popis: Purpose Obstructive sleep apnea (OSA) has been associated with changes in brain structure and regional function in certain brain areas. However, the functional features of network organization in the whole brain remain largely uncertain. The purpose of this study was to identify the OSA-related spatial centrality distribution of the whole brain functional network and to investigate the potential altered intrinsic functional hubs. Methods Forty male patients with newly confirmed severe OSA on polysomnography, and well-matched good sleepers, participated in this study. All participants underwent a resting-state functional MRI scan and clinical and cognitive evaluation. Voxel-wise degree centrality (DC) was measured across the whole brain, and group difference in DC was compared. The relationship between the abnormal DC value and clinical variables was assessed using a linear correlation analysis. Results Remarkably similar spatial distributions of the functional hubs (high DC) were found in both groups. However, OSA patients exhibited a pattern of significantly reduced regional DC in the left middle occipital gyrus, posterior cingulate cortex, left superior frontal gyrus, and bilateral inferior parietal lobule, and DC was increased in the right orbital frontal cortex, bilateral cerebellum posterior lobes, and bilateral lentiform nucleus, including the putamen, extending to the hippocampus, and the inferior temporal gyrus, which overlapped with the functional hubs. Furthermore, a linear correlation analysis revealed that the DC value in the posterior cingulate cortex and left superior frontal gyrus were positively correlated with Montreal cognitive assessment scores, The DC value in the left middle occipital gyrus and bilateral inferior parietal lobule were negatively correlated with apnea-hypopnea index and arousal index in OSA patients. Conclusion Our findings suggest that OSA patients exhibited specific abnormal intrinsic functional hubs including relatively reduced and increased DC. This expands our understanding of the functional characteristics of OSA, which may provide new insights into understanding the dysfunction and pathophysiology of OSA patients.
Databáze: OpenAIRE
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