Association of body mass index and age with incident diabetes in Chinese adults: a population-based cohort study
| Autor: | Shiwei Cui, Xiao-Ping Zhang, Bo Cai, Xiaohui Zhu, Xiao-Yi Zhang, Yun-Juan Gu, Xiao-Li Wu, Zhi-Qiang Lu, Xiao-Li Wang, Xiaoying Li, Yue-Hua Zhang, Jie Yuan, Ying Chen, Tong Yin |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male China 030209 endocrinology & metabolism body mass index Type 2 diabetes 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Diabetes mellitus Medicine Humans 030212 general & internal medicine Obesity Risk factor Young adult Aged Retrospective Studies Aged 80 and over business.industry Incidence Research young onset diabetes Age Factors Type 2 Diabetes Mellitus Retrospective cohort study General Medicine Fasting Middle Aged medicine.disease Diabetes and Endocrinology Diabetes Mellitus Type 2 ageing Female type 2 diabetes business Body mass index Demography |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectiveType 2 diabetes mellitus is increasing in young adults, and greater adiposity is considered a major risk factor. However, whether there is an association between obesity and diabetes and how this might be impacted by age is not clear. Therefore, we investigated the association between body mass index (BMI) and diabetes across a wide range of age groups (20–30, 30–40, 40–50, 50–60, 60–70 and ≥70 years old).DesignWe performed a retrospective cohort study using healthy screening programme data.SettingA total of 211 833 adult Chinese persons >20 years old across 32 sites and 11 cities in China (Shanghai, Beijing, Nanjing, Suzhou, Shenzhen, Changzhou, Chengdu, Guangzhou, Hefei, Wuhan, Nantong) were selected for the study; these persons were free of diabetes at baseline.Primary and secondary outcome measuresFasting plasma glucose levels were measured and information regarding the history of diabetes was collected at each visit. Diabetes was diagnosed as fasting plasma glucose ≥7.00 mmol/L and/or self-reported diabetes. Patients were censored at the date of diagnosis or the final visit, whichever came first.ResultsWith a median follow-up of 3.1 years, 4174 of the 211 833 participants developed diabetes, with an age-adjusted incidence rate of 7.35 per 1000 persons. The risk of incident diabetes increased proportionally with increasing baseline BMI values, with a 23% increased risk of incident diabetes with each kg/m2increase in BMI (95% CI 1.22 to 1.24). Across all age groups, there was a linear association between BMI and the risk of incident diabetes, although there was a stronger association between BMI and incident diabetes in the younger age groups (age×BMI interaction, pConclusionsAn increased BMI is also independently associated with a higher risk of developing diabetes in young adults and the effects of BMI on incident diabetes were accentuated in younger adults. |
| Databáze: | OpenAIRE |
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