The paradoxical role of IL-10 in immunity and cancer
| Autor: | Huaping Xiao, Mark R. Wakefield, Yujiang Fang, Mark H. Mannino, Qian Bai, Ziwen Zhu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
medicine.medical_treatment Cancer Autoimmunity Disease Biology medicine.disease Autoimmune Diseases Interleukin-10 Pathogenesis Interleukin 10 Cytokine Immune system Oncology Immunity Neoplasms Immunology medicine Tumor Microenvironment Animals Humans Receptors Interleukin-10 Function (biology) Signal Transduction |
| Zdroj: | Cancer letters. 367(2) |
| ISSN: | 1872-7980 |
| Popis: | Interleukin-10 (IL-10) produced by a wide-variety of cells is a highly pleiotropic cytokine. It has been implicated in the pathogenesis and/or development of autoimmune diseases and cancer, although it displays differential effects that seem to be contradictory sometimes. The ultimate role of this cytokine in disease, however, cannot be fully determined until the immunological contexts that regulate its function are further elucidated. In this review, we will discuss a wide variety of evidence of IL-10 in immunity and cancer in an effort to illuminate the remaining mysteries in the function of this cytokine that, when fully understood, may prove to be a powerful tool in the battle against cancer. |
| Databáze: | OpenAIRE |
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