Lymphadenectomy in surgical stage I epithelial ovarian cancer
| Autor: | Berit Jul Mosgaard, Ole Mogensen, Claus Høgdall, Marie Louise Nielsen, Kirsten Kock, Olivia Svolgaard, Øjvind Lidegaard, Lotte Nedergaard, Estrid Stæhr, Jan Blaakær, Erik Soegaard Andersen, Anni Grove, Marianne Lidang |
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| Rok vydání: | 2014 |
| Předmět: |
Ovarian Neoplasms/mortality
Adult medicine.medical_specialty Multivariate analysis Adolescent Denmark medicine.medical_treatment Ovary Disease Carcinoma Ovarian Epithelial Neoplasms Glandular and Epithelial/mortality Humans Medicine Epithelial ovarian cancer Neoplasms Glandular and Epithelial Prospective Studies Registries Prospective cohort study Lymph node Survival analysis Aged Neoplasm Staging Aged 80 and over Ovarian Neoplasms business.industry Lymph Node Excision/methods Obstetrics and Gynecology General Medicine Middle Aged Survival Analysis Surgery medicine.anatomical_structure Lymphatic Metastasis Lymph Nodes/pathology Lymph Node Excision Female Lymphadenectomy Lymph Nodes business |
| Zdroj: | Svolgaard, O, Lidegaard, O, Nielsen, M L S, Nedergaard, L, Mosgaard, B J, Lidang, M, Mogensen, O, Kock, K F, Blaakaer, J, Staehr, E, Søgaard-Andersen, E, Grove, A & Høgdall, C 2014, ' Lymphadenectomy in surgical stage I epithelial ovarian cancer ', Acta Obstetricia et Gynecologica Scandinavica, vol. 93, no. 3, pp. 256-260 . https://doi.org/10.1111/aogs.12322 Svolgaard, O, Lidegaard, O, Nielsen, M L, Nedergaard, L, Mosgaard, B J, Lidang, M, Mogensen, O, Kock, K, Blaakaer, J, Staehr, E, Andersen, E S, Grove, A & Høgdall, C 2014, ' Lymphadenectomy in surgical stage I epithelial ovarian cancer ', Acta Obstetricia et Gynecologica Scandinavica, vol. 93, no. 3, pp. 256–260 . https://doi.org/10.1111/aogs.12322 Svolgaard, O, Lidegaard, O, Nielsen, M L S, Nedergaard, L, Mosgaard, B J, Lidang, M, Mogensen, O, Kock, K, Blaakaer, J, Staehr, E, Andersen, E S, Grove, A & Høgdall, C 2014, ' Lymphadenectomy in surgical stage I epithelial ovarian cancer ', Acta Obstetrica et Gynecologica Scandinavica, vol. 93, no. 3, pp. 256-60 . https://doi.org/10.1111/aogs.12322 |
| ISSN: | 0001-6349 |
| DOI: | 10.1111/aogs.12322 |
| Popis: | OBJECTIVE: To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated. DESIGN: A prospective nationwide case-only study. SETTING: Denmark 2005-2011. SAMPLE: All women registered in the nationwide Danish Gynecologic Cancer Database from 1 January 2005 to 1 May 2011, presenting with a tumor macroscopically confined to the ovary without visible evidence of abdominal spread at the time of the initial exploration (surgical stage I). METHOD: Descriptive and survival analyses of data from Danish Gynecologic Cancer Database. MAIN OUTCOME MEASURES: The annual proportion of women with surgical stage I disease who received lymphadenectomy and the survival in the two groups. RESULTS: Of 2361 women with epithelial ovarian cancer, 627 were identified with surgical stage I. Lymphadenectomy was performed in 216 women (34%) of whom 13 (6%) had lymph node metastases. At 5-year follow up 85% remained alive in the lymphadenectomy group compared with 80% in the control group (p = 0.064). The lymphadenectomy fraction increased from 24% in 2005 to 55% in 2011. When univariate and multivariate analyses were conducted only an insignificant difference in the survival probability was found between lymphadenectomy and no lymphadenectomy in women presenting with tumor macroscopically confined to the ovary. CONCLUSION: Although increasing, the number of women with surgical stage I disease in Denmark who receive lymphadenectomy remains low, but this did not seem to make a difference to survival. |
| Databáze: | OpenAIRE |
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