Actions of the novel bronchodilator, trimetaquinol, on bovine pulmonary vein
| Autor: | Peter Eyre, Christopher J. Hanna, Ann Hambleton |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Pharmacology
Serotonin Physiology medicine.drug_class business.industry Histamine Antagonists Isoproterenol General Medicine In Vitro Techniques Isoquinolines Muscle Smooth Vascular Pulmonary vein Smooth muscle Pulmonary Veins Physiology (medical) Bronchodilator Anesthesia medicine Animals Cattle Tretoquinol Serotonin Antagonists business Muscle Contraction |
| Zdroj: | Canadian journal of physiology and pharmacology. 58(1) |
| ISSN: | 0008-4212 |
| Popis: | The actions of the β-sympathomimetic bronchodilator trimetaquinol (TMQ) were examined on bovine pulmonary vein smooth muscle in vitro. TMQ partially and reversibly inhibited 5-hydroxytryptamine (5HT) induced contractions of the vein strips. The relaxant activity was neither blocked by propranolol (10−7 M) nor enhanced by phentolamine (10−7 M). Isoproterenol, alone or in the presence of phentolamine (10−7 M), was much less effective than TMQ in relaxing 5HT-induced contractions. From these results it is suggested that TMQ functions via a "non-β-adrenergic" mechanism to relax bovine pulmonary vein smooth muscle. |
| Databáze: | OpenAIRE |
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