Simultaneous determination of 42 pharmaceuticals in seafood samples by solvent extraction coupled to liquid chromatography–tandem mass spectrometry

Autor: Mathilde Monperrus, Laurent Lanceleur, Tiphaine Mille, Carole Miossec
Přispěvatelé: Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), European Project: MICROPOLIT
Rok vydání: 2020
Předmět:
Analyte
Tandem mass spectrometry
Fish tissueL
Food Contamination
Chemical Fractionation
Mass spectrometry
01 natural sciences
Analytical Chemistry
Emerging pollutants
0404 agricultural biotechnology
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Liquid chromatography–mass spectrometry
14. Life underwater
Solvent extraction
iquid chromatography
Chromatography
Chemistry
Muscles
010401 analytical chemistry
Extraction (chemistry)
[CHIM.MATE]Chemical Sciences/Material chemistry
04 agricultural and veterinary sciences
General Medicine
Contamination
040401 food science
Multi-residue method
0104 chemical sciences
[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry
[CHIM.POLY]Chemical Sciences/Polymers
Pharmaceutical Preparations
Seafood
Cardiovascular agent
Solvents
Pharmaceuticals
France
Food Analysis
Water Pollutants
Chemical
Chromatography
Liquid
Food Science
Zdroj: Food Chemistry
Food Chemistry, Elsevier, 2020, 322, pp.126765. ⟨10.1016/j.foodchem.2020.126765⟩
Food Chemistry, 2020, 322, pp.126765. ⟨10.1016/j.foodchem.2020.126765⟩
ISSN: 0308-8146
1873-7072
DOI: 10.1016/j.foodchem.2020.126765
Popis: International audience; An efficient and sensitive analytical method based on liquid chromatography–tandem mass spectrometry (LC–MS/MS) has been developed and validated for the simultaneous determination of 42 pharmaceuticals belonging to different therapeutic classes (i.e. antibiotics, analgesics, anti-inflammatories, cardiovascular agents, anxiolytics and human indicators) in seafood samples. The very simple sample preparation included analytes extraction with acidified methanol, concentration by evaporation and filtration of the final extract prior to LC–MS/MS analysis. Analytical performances were evaluated in muscles of four commercial species (hake, red mullet, sole and shrimp) and showed good recoveries at two spiked concentration levels, with relative standard deviations below 45%. Limits of quantification ranged from 0.1 to 40.2 ng/g. This procedure has been successfully applied to the determination of the target analytes in seafood collected from the Bay of Biscay (Southern France) and 4 of these 42 pharmaceuticals were detected at low ng/g levels, suggesting a very limited contamination.
Databáze: OpenAIRE
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