Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice

Autor: Naiara Zoccal Saraiva, Luiz Sergio Camargo, Michele Munk, Humberto Brandão, Carolina Capobiango R. Quintão
Přispěvatelé: CAROLINA CAPOBIANGO ROMANO QUINTAO, CNPGL, LUIZ SERGIO DE ALMEIDA CAMARGO, CNPGL, HUMBERTO DE MELLO BRANDAO, CNPGL, NAIARA ZOCCAL SARAIVA, CNPGL, MICHELE MUNK, Universidade Federal de Juiz de Fora.
Rok vydání: 2022
Předmět:
Zdroj: Einstein
einstein (São Paulo) v.20 2022
Einstein (São Paulo)
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron:IIEPAE
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice)
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
Einstein (São Paulo), Volume: 20, Article number: eRB5898, Published: 21 FEB 2022
ISSN: 2317-6385
1679-4508
DOI: 10.31744/einstein_journal/2022rb5898
Popis: The delivery of nucleic acids to cells is considered a crucial step for the success of genetic modifications aimed at therapeutic purposes or production of genetically modified animals. In this context, nanotechnology is one of the most promising fields of science, with the potential to solve several existing problems. Nanostructures have desirable characteristics to be used as carriers, such as nanometric size, large surface area, cell internalization capacity, prolonged and controlled release, among others. Genetically modified animals can contribute to the production of biopharmaceuticals, through the expression of high-associated-value molecules. The production of these animals, also known as biofactories, further enhances Brazilian agribusiness, since it allows adding value to the final product, and favors the integration between the agricultural market and the pharmaceutical sector. However, there is a growing concern about the safety and possible harmful effects of nanostructures, since data on the safe use of these materials are still insufficient. The objective of this review was to address aspects of the use of nanostructures, mainly carbon nanotubes as nucleic acid carriers, aiming at the production of genetically modified animals, with the certainty that progress in this field of knowledge depends on more information on the mechanisms of interaction between nanostructures, cells and embryos, as well as on its toxicity. Made available in DSpace on 2022-05-10T16:12:42Z (GMT). No. of bitstreams: 1 Challenges-use-nanostructures.pdf: 603206 bytes, checksum: 533820a862c7319ede6a9cab4fb3fa87 (MD5) Previous issue date: 2022
Databáze: OpenAIRE
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