Establishing reference values for macro- and microvascular measurements in 4-to-5 year-old children of the ENVIRONAGE prospective birth cohort

Autor: Eline B. Provost, Jos Op 't Roodt, Yinthe Dockx, Patrick De Boever, Karen Vrijens, Leen J. Luyten, Hanne Sleurs, Narjes Madhloum, Michelle Plusquin, Tim S. Nawrot
Přispěvatelé: De Boever, Patrick/0000-0002-5197-8215, MUMC+: HVC Pieken Maastricht Studie (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
IMPACT
CHILDHOOD
lcsh:Medicine
BLOOD-PRESSURE
Blood Pressure
ADULTHOOD
Total population
030204 cardiovascular system & hematology
INTIMA-MEDIA THICKNESS
Carotid Intima-Media Thickness
0302 clinical medicine
Reference Values
Risk Factors
CARDIOVASCULAR RISK-FACTORS
030212 general & internal medicine
Prospective Studies
Carotid-Artery Intima
lcsh:Science
Multidisciplinary
ASSOCIATION
Adulthood
3. Good health
Multidisciplinary Sciences
Impact
Carotid Arteries
Cardiovascular Diseases
Child
Preschool
Blood-Pressure
Cardiology
Science & Technology - Other Topics
Population study
Female
CAROTID-ARTERY INTIMA
Birth cohort
medicine.medical_specialty
Cardiovascular risk factors
Intima-Media Thickness
Article
Association
03 medical and health sciences
Age
AGE
Vascular Stiffness
Internal medicine
Elastic Modulus
medicine
Humans
Science & Technology
business.industry
lcsh:R
Cardiovascular Risk-Factors
Atherosclerosis
Childhood
Elasticity
Compliance (physiology)
Environmental sciences
Blood pressure
ATHEROSCLEROSIS
Intima-media thickness
Reference values
lcsh:Q
business
Biomarkers
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports, 10(1):5107. Nature Publishing Group
Madhloum, N, Luyten, L J, Provost, E B, De Boever, P, Dockx, Y, Sleurs, H, Plusquin, M, Roodt, J O, Vrijens, K & Nawrot, T S 2020, ' Establishing reference values for macro-and microvascular measurements in 4-to-5 year-old children of the ENVIRONAGE prospective birth cohort ', Scientific Reports, vol. 10, no. 1, 5107 . https://doi.org/10.1038/s41598-020-61987-z
ISSN: 2045-2322
Popis: Cardiovascular risk factors are usually better tolerated, and can therefore be perceived as less harmful, at a young age. However, over time the effects of these adverse factors may persist or accumulate and lead to excess morbidity and mortality from cardiovascular diseases later in life. Until now, reference values for the basic cardiovascular health characteristics of 4-to-6 year-old children are lacking. Within a follow-up study of the ENVIRONAGE (ENVIRonmental influence ON early AGE) birth cohort we assessed various cardiovascular measurements in 288 children aged 4-5 years. For the macrovasculature, we measured their blood pressure and examined the intima-media thickness of the carotid artery (CIMT), the arterial elasticity (including the pulse-wave velocity (PWV), carotid distensibility (DC) and compliance (CC) coefficients), the carotid beta stiffness index (SI beta) and Young's Elastic Modulus (YEM). Retinal microvascular traits included the Central Retinal Arteriolar Equivalent (CRAE) and Central Retinal Venular Equivalent (CRVE). Age of the study population averaged (+/- SD) 4.2 (+/- 0.4 years. Mean systolic and diastolic blood pressure were 97.9 (+/- 8.1) mmHg and 54.7(+/- 7.6) mmHg, respectively. CIMT for the total population averaged 487.1 (+/- 68.1) mu m. The average stiffness values for DC, CC, SI beta, and PWV were 78.7 (+/- 34.2) 10-(3)/kPa, 1.61 (+/- 0.59) mm(2)/kPa and 4.4 (+/- 2.4), and 3.7 m/s (+/- 0.9) respectively. The mean determined for YEM was 163.2 kPa (+/- 79.9). Concerning the microvasculature, the average CRAE was 180.9 (+/- 14.2) mu m and the corresponding value for CRVE was 251.0 (+/- 19.7) mu m. In contrast to the macrovasculature, a significant gender-related difference existed for the microvasculature: in boys, both the CRAE (178.8 mu m vs 182.6 mu m; p = 0.03) and CRVE (247.9 mu m vs 254.0 mu m; p = 0.01) were narrower than in girls. We have provided reference values for young children to understand changes in the early cardiovascular health trajectory. Establishing these reference values of cardiovascular phenotypes at this young age is necessary to develop targeted health promotion strategies as well as for better understanding of the life course changes of both small and large blood vessels. The authors thank all children and parents for taking part in the study. The ENVIRONAGE birth cohort and follow-up study are supported by grants from the European Research Council (ERC-2012-StG310898) and the Flemish Scientific Fund (FWO, 1516112 N/G.0873.11.N.10). Nawrot, TS (corresponding author), Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium ; Leuven Univ, Dept Publ Hlth & Primary Care, Occupat & Environm Med, Leuven, Belgium. tim.nawrot@uhasselt.be
Databáze: OpenAIRE
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