The Effect of Flow Rate on a Third-Generation Sub-Ohm Tank Electronic Nicotine Delivery System—Comparison of CORESTA Flow Rates to More Realistic Flow Rates
| Autor: | Toluwanimi Oni, Sara Greenlee, Evan L. Floyd, Lurdes Queimado, Balaji Sadhasivam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nicotine
Health Toxicology and Mutagenesis Nicotine Dose 010501 environmental sciences Electronic Nicotine Delivery Systems 01 natural sciences Article 03 medical and health sciences 0302 clinical medicine nicotine yield Statistics PMTAs 030212 general & internal medicine power settings Ohm Nicotine yield CORESTA 0105 earth and related environmental sciences Aerosols Vaping Public Health Environmental and Occupational Health Third generation Volumetric flow rate Nicotine delivery electronic cigarettes Environmental science Medicine flow rate Pyrolysis |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 7535, p 7535 (2021) Volume 18 Issue 14 |
| ISSN: | 1660-4601 1661-7827 |
| Popis: | Many types of electronic cigarettes (ECs) are currently in use, but the default flow rate used to simulate puffing is centered on tobacco cigarette flow rates. CORESTA offers several methods and technical guides for evaluation of ECs but there are few puffing topography studies focusing on sub-ohm ECs differences between real-world usage and that found in the literature appear large. This study focuses on how power and flow rate affect the nicotine yield of a sub-ohm EC. A puffing system (Puff3rd) has been designed and used to produce and collect EC aerosol. Nicotine yield was measured by GC–MS at three power levels and four flow rates. Data analysis was conducted in SAS using the MIXED procedure. Power, flow rate, and their interaction were all significant predictors of nicotine yield. Nicotine yield increased with both the vaping power and the puff flow rate with significant interaction of the two. Findings indicate that using the current CORESTA flow rate (1100 mL/min) to evaluate third-generation ECs underestimates nicotine yield and likely overestimates pyrolysis products. Real users are expected to have 2–3× the nicotine dose measured at 1100 mL/min, which could confound epidemiological studies seeking to link nicotine delivery to product satisfaction and acceptability. |
| Databáze: | OpenAIRE |
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