Aortic atherosclerosis in white carneau pigeons: the effect of hypercholesterolemia and certain hypocholesterolemic agents
| Autor: | B.A. Kottke, Bollman Jl, J.L. Juergens |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Arteriosclerosis Hypercholesterolemia Aortic Diseases Lipid Metabolism Disorders Blood lipids Niacin chemistry.chemical_compound Blood serum Internal medicine Ammonium Compounds medicine Animals Columbidae Aortic atherosclerosis Carneau Sclerosis Cholestyramine biology Cholesterol Nicotinic Acids General Medicine medicine.disease biology.organism_classification Quaternary Ammonium Compounds Endocrinology chemistry Alcohols lipids (amino acids peptides and proteins) Thyroid function hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Atherosclerosis Research. 3:129-136 |
| ISSN: | 0368-1319 |
| DOI: | 10.1016/s0368-1319(63)80083-6 |
| Popis: | Summary The effects of hypercholesterolemia secondary to induced hypothyroidism and of hypercholesterolemia produced by cholesterol feeding on spontaneous atherosclerosis of the White Carneau pigeon was investigated. The degree of atherosclerosis in a group of hypothyroid hypercholesterolemic birds was similar to that in euthyroid normocholesterolemic controls. Feeding dietary cholesterol to normal adult pigeons of this species did not aggravate the degree of atherosclerosis unless plasma cholesterol levels greater than 1500 mg/100 ml were produced. Triparanol produced some lowering of plasma cholesterol levels in normal pigeons but had no effect on the cholesterol levels of the hypothyroid birds. Nicotinic acid and cholestyramine had no effect on the plasma cholesterol levels of either normal or hypothyroid hypercholesterolemic pigeons. None of the three drugs studied had any effect on atherosclerosis in either normal or hypothyroid hypercholesterolemic groups of pigeons. Triparanol was found to be toxic to this species. |
| Databáze: | OpenAIRE |
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