Single and Joined Behaviour of Circulating Biomarkers and Metabolic Parameters in High-Fit and Low-Fit Healthy Females

Autor:	Joëlle J. E. Janssen, Bart Lagerwaard, Arie G. Nieuwenhuizen, Xavier Escoté, Núria Canela, Josep M. del Bas, Vincent C. J. de Boer, Jaap Keijer
Rok vydání:	2023
Předmět:	lifestyle exercise Organic Chemistry circulating biomarkers health aerobic fitness level females General Medicine Catalysis Computer Science Applications Inorganic Chemistry Human and Animal Physiology WIAS Fysiologie van Mens en Dier human Physical and Theoretical Chemistry Molecular Biology Spectroscopy VLAG
Zdroj:	International Journal of Molecular Sciences 24 (2023) 4 International Journal of Molecular Sciences, 24(4) International Journal of Molecular Sciences Volume 24 Issue 4 Pages: 4202
ISSN:	1422-0067 1661-6596
Popis:	Biomarkers are important in the assessment of health and disease, but are poorly studied in still healthy individuals with a (potential) different risk for metabolic disease. This study investigated, first, how single biomarkers and metabolic parameters, functional biomarker and metabolic parameter categories, and total biomarker and metabolic parameter profiles behave in young healthy female adults of different aerobic fitness and, second, how these biomarkers and metabolic parameters are affected by recent exercise in these healthy individuals. A total of 102 biomarkers and metabolic parameters were analysed in serum or plasma samples from 30 young, healthy, female adults divided into a high-fit (V̇O2peak ≥ 47 mL/kg/min, N = 15) and a low-fit (V̇O2peak ≤ 37 mL/kg/min, N = 15) group, at baseline and overnight after a single bout of exercise (60 min, 70% V̇O2peak). Our results show that total biomarker and metabolic parameter profiles were similar between high-fit and low-fit females. Recent exercise significantly affected several single biomarkers and metabolic parameters, mostly related to inflammation and lipid metabolism. Furthermore, functional biomarker and metabolic parameter categories corresponded to biomarker and metabolic parameter clusters generated via hierarchical clustering models. In conclusion, this study provides insight into the single and joined behavior of circulating biomarkers and metabolic parameters in healthy females, and identified functional biomarker and metabolic parameter categories that may be used for the characterisation of human health physiology.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b1cf76fa4d498bbfccb7f3e38f5d38 https://doi.org/10.3390/ijms24044202 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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