Gender and chronological age affect erythrocyte membrane oxidative indices in citrate phosphate dextrose adenine-formula 1 (CPDA-1) blood bank storage condition
| Autor: | Ahmet Belce, Ufuk Çakatay, Uğur Aksu, Ahmet Dogukan Kansu, Remisa Gelisgen, Seval Aydin, Pinar Atukeren, Duygu Uzun, Tamer Cebe, Hayriye Erman, Ezel Uslu |
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| Přispěvatelé: | BELCE, AHMET, KANSU, ABDULLAH |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Aging Antioxidant Physiology medicine.medical_treatment Biophysics 030209 endocrinology & metabolism Oxidative phosphorylation Biology medicine.disease_cause Antioxidants Phosphates 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sex Factors Glycation Internal medicine medicine Animals Citrates Rats Wistar Adenine Erythrocyte Membrane General Medicine Sialic acid Rats 030104 developmental biology Membrane Endocrinology Glucose chemistry Blood Preservation Ferric Blood Banks Female Oxidation-Reduction Oxidative stress Homeostasis medicine.drug |
| Zdroj: | General physiology and biophysics. 35(3) |
| ISSN: | 0231-5882 |
| Popis: | It is well known that in vitro storage lesions lead to membrane dysfunction and decreased number of functional erythrocytes. As erythrocytes get older, in storage media as well as in peripheral circulation, they undergo a variety of biochemical changes. In our study, the erythrocytes with different age groups in citrate phosphate dextrose adenine-formula 1 (CPDA-1) storage solution were used in order to investigate the possible effect of gender factor on oxidative damage. Oxidative damage biomarkers in erythrocyte membranes such as ferric reducing antioxidant power, pro-oxidant-antioxidant balance, protein-bound advance glycation end products, and sialic acid were analyzed. Current study reveals that change in membrane redox status during blood-bank storage condition also depends on both gender depended homeostatic factors and the presence of CPDA-1. During the storage period in CPDA-1, erythrocytes from the male donors are mostly affected by free radical-mediated oxidative stress but erythrocytes obtained from females are severely affected by glyoxidative stress. |
| Databáze: | OpenAIRE |
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