Aberrant Early in Life Stimulation of the Stress-Response System Affects Emotional Contagion and Oxytocin Regulation in Adult Male Mice

Autor: Carla Petrella, Giovanni Laviola, Noemi Meschino, Marco Fiore, Ludovica Maria Busdraghi
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
Emotions
Receptors
Opioid
mu
Physiology
Pituitary-Adrenal System
Stimulation
Oxytocin
Psychological Distress
chemistry.chemical_compound
Mice
stress
0302 clinical medicine
Corticosterone
Lactation
Medicine
empathy for pain
Biology (General)
Spectroscopy
General Medicine
Computer Science Applications
Chemistry
medicine.anatomical_structure
HPA
Female
Glucocorticoid
medicine.drug
Hypothalamo-Hypophyseal System
QH301-705.5
Offspring
early risk factors
social disorders
oxytocin
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Receptors
Glucocorticoid
Genetic predisposition
Animals
Humans
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
Pregnancy
behavior
business.industry
Organic Chemistry
medicine.disease
030104 developmental biology
Receptors
Mineralocorticoid
chemistry
business
030217 neurology & neurosurgery
Stress
Psychological
Zdroj: International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 5039, p 5039 (2021)
International journal of molecular sciences
22 (2021). doi:10.3390/ijms22095039
info:cnr-pdr/source/autori:Laviola G.; Busdraghi L.M.; Meschino N.; Petrella C.; Fiore M./titolo:Aberrant early in life stimulation of the stress-response system affects emotional contagion and oxytocin regulation in adult male mice/doi:10.3390%2Fijms22095039/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
ISSN: 1422-0067
DOI: 10.3390/ijms22095039
Popis: Results over the last decades have provided evidence suggesting that HPA axis dysfunction is a major risk factor predisposing to the development of psychopathological behaviour. This susceptibility can be programmed during developmental windows of marked neuroplasticity, allowing early-life adversity to convey vulnerability to mental illness later in life. Besides genetic predisposition, also environmental factors play a pivotal role in this process, through embodiment of the mother’s emotions, or via nutrients and hormones transferred through the placenta and the maternal milk. The aim of the current translational study was to mimic a severe stress condition by exposing female CD-1 mouse dams to abnormal levels of corticosterone (80 µg/mL) in the drinking water either during the last week of pregnancy (PreCORT) or the first one of lactation (PostCORT), compared to an Animal Facility Rearing (AFR) control group. When tested as adults, male mice from PostCORT offspring and somewhat less the PreCORT mice exhibited a markedly increased corticosterone response to acute restraint stress, compared to perinatal AFR controls. Aberrant persistence of adolescence-typical increased interest towards novel social stimuli and somewhat deficient emotional contagion also characterised profiles in both perinatal-CORT groups. Intranasal oxytocin (0 or 20.0 µg/kg) generally managed to reduce the stress response and restore a regular behavioural phenotype. Alterations in density of glucocorticoid and mineralocorticoid receptors, oxytocin and µ- and κ-opioid receptors were found. Changes differed as a function of brain areas and the specific age window of perinatal aberrant stimulation of the HPA axis. Present results provided experimental evidence in a translational mouse model that precocious adversity represents a risk factor predisposing to the development of psychopathological behaviour.
Databáze: OpenAIRE
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