Survival Outcomes After Immediate Radical Cystectomy Versus Conservative Management with Bacillus Calmette-Guérin Among T1 High-grade Micropapillary Bladder Cancer Patients: Results from a Multicentre Collaboration

Autor: Andrea Necchi, Andrea Mari, Francesco Soria, Marco Moschini, Livio Mordasini, Soichiro Yoshida, Luca Afferi, Morgan Rouprêt, Shahrokh F. Shariat, Yasuhisa Fujii, Kees Hendricksen, Alessandro Antonelli, Paolo Gontero, Philipp Baumeister, Rodolfo Hurle, Renzo Colombo, David D'Andrea, Wojciech Krajewski, Agostino Mattei, Gerald Schulz, Chiara Lonati, Jeremy Yuen-Chun Teoh, Alberto Briganti, Ekaterina Laukhtina, Tobias Klatte, M. Carmen Mir, Claudio Simeone, Alberto Martini, Alexandra Masson-Lecomte, Stefania Zamboni, Andrea Minervini, Anne Sophie Valiquette, Maria Angela Cerruto, Sosan Azizi, Roberto Carando, Alessandro Tafuri, Roberto Contieri, Giancarlo Marra, Francesco Montorsi
Přispěvatelé: Lonati, Chiara, Baumeister, Philipp, Afferi, Luca, Mari, Andrea, Minervini, Andrea, Krajewski, Wojciech, Azizi, Sosan, Hendricksen, Kee, Martini, Alberto, Necchi, Andrea, Montorsi, Francesco, Briganti, Alberto, Colombo, Renzo, Tafuri, Alessandro, Antonelli, Alessandro, Cerruto, Maria Angela, Rouprêt, Morgan, Masson-Lecomte, Alexandra, Laukhtina, Ekaterina, D'Andrea, David, Shariat, Shahrokh F, Soria, Francesco, Marra, Giancarlo, Gontero, Paolo, Contieri, Roberto, Hurle, Rodolfo, Valiquette, Anne Sophie, Mir, M Carmen, Zamboni, Stefania, Simeone, Claudio, Klatte, Tobia, Teoh, Jeremy Yuen-Chun, Yoshida, Soichiro, Fujii, Yasuhisa, Carando, Roberto, Schulz, Gerald B, Mordasini, Livio, Mattei, Agostino, Moschini, Marco
Rok vydání: 2021
Předmět:
Zdroj: European urology focus. 8(5)
ISSN: 2405-4569
Popis: Background Literature lacks clear evidence regarding the optimal treatment for non–muscle-invasive micropapillary bladder cancer (MPBC) due to its rarity and the presence of only small sample size and single-centre studies. Objective To assess cancer-specific mortality (CSM) and overall mortality (OM) between immediate radical cystectomy (RC) and conservative management among T1 high-grade (HG) MPBC. Design, setting, and participants We retrospectively analysed a multicentre dataset including 119 T1 HG MPBC patients treated between 2005 and 2019 at 15 tertiary referral centres. The median follow-up time was 35 mo (interquartile range: 19–64). Intervention Patients underwent immediate RC versus conservative management with bacillus Calmette-Guerin. Outcomes measurements and statistical analysis Cumulative incidence functions and Kaplan-Meier methods were applied to estimate survival outcomes. Multivariable Cox analyses were performed to assess independent predictors of disease recurrence and disease progression after conservative management; covariates consisted of pure MPBC, concomitant lymphovascular invasion (LVI), and carcinoma in situ at initial diagnosis. Results and limitations Immediate RC and conservative management were performed in 27% and 73% of patients, respectively. CSM and OM did not differ significantly among patient treated with immediate RC versus conservative management (Pepe-Mori test p = 0.5 and log-rank test p = 0.9, respectively). Overall, 66.7% and 34.5% of patients experienced disease recurrence and disease progression after conservative management, respectively. At multivariable Cox analyses, concomitant LVI was an independent predictor of disease recurrence (p = 0.01) and progression (p = 0.03), while pure MPBC was independently associated with disease progression (p = 0.03). The absence of a centralised re-review and the retrospective design represent the main limitations of our study. Conclusions Conservative management could achieve satisfactory results among T1 HG MPBC patients with neither pure MPBC nor LVI at initial diagnosis. Patient summary Bacillus Calmette-Guerin seems to be an effective therapy for T1 micropapillary bladder cancer patients with neither pure micropapillary disease nor lymphovascular invasion at initial diagnosis.
Databáze: OpenAIRE
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