Alzheimer and platelets: Low-density platelet populations reveal increased serotonin content in Alzheimer type dementia
| Autor: | Staffan Nilsson, Micha Milovanovic, Bengt Winblad, Claes Post, Petter Järemo, Tomas L. Lindahl, Kristoffer Eriksson |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Platelets
Male Serotonin medicine.medical_specialty Clinical Biochemistry Population Fibrinogen Pathogenesis Alzheimer Disease Internal medicine Humans Medicine Dementia Platelet Platelet activation education Aged education.field_of_study Amyloid beta-Peptides business.industry General Medicine medicine.disease Endocrinology Immunology Female business Reuptake inhibitor medicine.drug |
| Zdroj: | Clinical Biochemistry. 47:51-53 |
| ISSN: | 0009-9120 |
| Popis: | Introduction Alzheimer's disease (AD) is a progressive form of dementia characterized by an increase in the toxic substance β-amyloid in the brain. Platelets display a substantial heterogeneity with respect to density. They further contain a substantial amount of β-amyloid precursor protein. Platelets take up and store serotonin (5-HT) that plays an important role in the pathogenesis of severe depression. The current study aims to investigate platelet serotonin content in different platelet density populations. Material and methods The study involved 8 patients (age 70 ± 8 (SD) years) (3 females/5 males) with moderate AD. 6 healthy elderly subjects (age 66 ± 9 (SD) years) (3 females/3 males) served as controls. The platelet population was divided into 17 subpopulations according to density, using a linear Percoll™ gradient. Platelets were counted in all fractions. After cell lysis an ELISA technique was employed to determine the 5-HT content in each platelet subfraction. Results The two study groups did not differ significantly regarding platelet distribution in the gradients, but AD sufferers have a significantly higher 5-HT content ( p Discussion AD-type dementia proved to be associated with lighter platelets containing more 5-HT. It is possible that platelets from AD patients release less 5-HT. It is speculated that AD synapses are affected in a manner comparable to platelets, which could explain why 5-HT reuptake inhibitors are less effective in AD dementia. |
| Databáze: | OpenAIRE |
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