Adverse Alterations in Bone Metabolism Are Associated with Lung Infection in Adults with Cystic Fibrosis
| Autor: | Ashley R. Stephens, Robert K. Lark, A. Denene Blackwood, Robert M. Aris, David A. Ontjes, Gayle E. Lester, Margaret Hensler, Isabel P. Neuringer |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Lung Diseases Male Pulmonary and Respiratory Medicine medicine.medical_specialty Adolescent Cystic Fibrosis Osteocalcin Inflammation Critical Care and Intensive Care Medicine Cystic fibrosis Bone and Bones Collagen Type I Proinflammatory cytokine Bone remodeling chemistry.chemical_compound Adipokines Lectins Internal medicine medicine Humans Chitinase-3-Like Protein 1 Prospective Studies Amino Acids Respiratory Tract Infections Glycoproteins Creatinine business.industry Respiratory disease Interleukin medicine.disease C-Reactive Protein Endocrinology chemistry Cytokines Female Collagen medicine.symptom Peptides business Biomarkers Type I collagen |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 162:1674-1678 |
| ISSN: | 1535-4970 1073-449X |
| Popis: | Low bone density, fractures, and kyphosis complicate the lives of adults with cystic fibrosis (CF), and inflammatory cytokines (interleukin [IL]-1beta, IL-6, and tumor necrosis factor [TNF]-alpha) that may alter bone metabolism have been previously found to be increased in the lungs and serum of CF patients. The objective of this prospective study was to determine the impact of lung infection on bone physiology in 17 adult CF patients. Serum osteocalcin, a marker of bone formation; urine N-telopeptides of type I collagen and free deoxypyridinoline, both of which are markers of bone breakdown; serum cytokines (TNF-alpha, IL-1beta, and IL-6); and general inflammatory markers (serum C-reactive protein [CRP] and chondrex) were measured at the beginning and end of treatment for an acute exacerbation of lung infection and again 3 wk later. After treatment with conventional antibiotics, decreases in N-telopeptides (147.3 +/- 77.5 [mean +/- SEM] versus 95.5 +/- 57.3 bone collagen equivalents (BCE)/mmol creatinine, p = 0.0014), deoxypyridinoline (8.42 +/- 2.8 versus 6.8 +/- 3.0 mmol/mmol creatinine, p = 0.08), IL-1beta (1.43 +/- 1.13 versus 0.65 +/- 0.63 pg/ml, p = 0.03), IL-6 (9.5 +/- 6.5 versus 4.7 +/- 3.2 pg/ml, p = 0. 012), CRP (43.1 +/- 29.3 versus 23.4 +/- 25.3 mg/ml, p = 0.04), and chondrex (151.7 +/- 111.7 versus 101.4 +/- 67.3 ng/ml, p = 0.014), and increases in osteocalcin levels (14.5 +/- 5.4 versus 22.5 +/- 8. 7 ng/ml, p = 0.010) were observed. Three weeks later, the changes in N-telopeptides and osteocalcin persisted. These data indicate that pulmonary infection, through the elaboration of inflammatory cytokines, may be linked to increased bone resorption and diminished bone formation. These results provide insights into the impact of systemic inflammation on bone health, and suggest novel mechanisms for bone disease in CF. |
| Databáze: | OpenAIRE |
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