Force-controlled ultrasound to measure passive mechanical properties of muscle in Duchenne muscular dystrophy
| Autor: | Anne J. Pigula, Basil T. Darras, Matthew W. Gilbertson, Brian W. Anthony, Seward B. Rutkove, Jim S. Wu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
Male congenital hereditary and neonatal diseases and abnormalities Adolescent Duchenne muscular dystrophy Population Biceps 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Elastic Modulus medicine Humans education Child Muscle Skeletal Elastic modulus Ultrasonography education.field_of_study business.industry Ultrasound Skeletal muscle Extremities Anatomy medicine.disease Ultrasonic imaging Muscular Dystrophy Duchenne medicine.anatomical_structure Child Preschool business 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | EMBC |
| ISSN: | 2694-0604 |
| Popis: | The purpose of this study is to assess differences in skeletal muscle compressibility between patients with Duchenne muscular dystrophy (DMD) and normal subjects. The transverse passive mechanical properties of muscle, particularly those related to stiffness and elasticity, can be measured using force-controlled ultrasound. We acquired ultrasound videos of muscle compression under known pressures in the biceps and quadriceps in 23 boys with DMD and 20 age-matched healthy controls. We calculated the bulk linear spring constant, nonlinear stress-strain response, and average Young's modulus for each. Young's modulus was found to be significantly higher in the DMD population in both the biceps (normal: 33 ± 6 kPa, DMD: 45 ± 14, p < .01) and quadriceps (normal: 42 ± 6, DMD: 58 ± 14, p < .0001). Muscle compressibility measured by force-controlled ultrasound is an objective and robust technique to quantitatively monitor the effects of DMD and distinguish from normal subjects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|