Metallopolymer-Peptide Hybrid Materials: Synthesis and Self-Assembly of Functional, Polyferrocenylsilane-Tetrapeptide Conjugates
| Autor: | Siree Tangbunsuk, Derek N. Woolfson, George R. Whittell, Maxim G. Ryadnov, Guido W. M. Vandermeulen, Ian Manners |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Magnetic Resonance Spectroscopy Molecular Structure Tetrapeptide Polymers Organic Chemistry Beta sheet Nanoparticle Peptide General Chemistry Silanes Catalysis Silver nanoparticle Crystallinity chemistry Polymer chemistry Nanoparticles Ferrous Compounds Self-assembly Hybrid material Oligopeptides |
| Zdroj: | Chemistry - A European Journal. 18:2524-2535 |
| ISSN: | 0947-6539 |
| DOI: | 10.1002/chem.201102223 |
| Popis: | Conjugates of poly(ferroce- nyldimethylsilane) (PFDMS) with Ac- (GA)2-OH, Ac-A4-OH, Ac-G4-OH and Ac-V4-OH have been prepared by re- action of the tetrapeptide units with the amino-terminated metallopolymer. The number average degree of poly- merisation (DPn) of the PFDMS was approximately 20 and comparable ma- terials with shorter (DPn � 10) and/or amorphous chains have been prepared by the same procedure. Poly(ferroceny- lethylmethylsilane) (PFEMS) was em- ployed for the latter purpose. All con- jugates were characterised by GPC, MALDI-TOF MS, NMR and IR spec- troscopy. With the exception of Ac-V4- PFDMS20, all materials exhibited some anti-parallel b-sheet structure in the solid state. The self-assembly of the conjugates was studied in toluene by DLS. The vast majority of the materi- als, irrespective of peptide sequence or chain crystallinity, afforded fibres con- sisting of a peptidic core surrounded by a PFS corona. These fibres were found in the form of cross-linked networks by TEM and AFM. The accessibility of the chemically reducing PFS corona has been demonstrated by the localised formation of silver nanoparticles on the surface of the fibres. |
| Databáze: | OpenAIRE |
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