Eco-Friendly Rapid Synthesis of 3-Substituted-2-Thioxo-2,3-Dihydroquinazolin-4(1H)-Ones in Choline Chloride Based Deep Eutectic Solvent
| Autor: | Tena Tarnai, Jelena Klenkar, Maja Molnar |
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| Rok vydání: | 2020 |
| Předmět: |
010405 organic chemistry
Organic Chemistry deep eutectic solvents 2-thioxo-2 3-dihydroquinazolin-4(1H)-ones anthranilic acid 5-iodoanthranilic acid isothiocyanate 010402 general chemistry 01 natural sciences Environmentally friendly 0104 chemical sciences Catalysis Deep eutectic solvent chemistry.chemical_compound chemistry Urea Anthranilic acid Organic chemistry Choline chloride |
| DOI: | 10.6084/m9.figshare.4896503 |
| Popis: | A series of 3-substituted-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones and 6-iodo-3-substituted-2-thioxo-2,3-dihydroquinazolin-4(1H)-ones were synthesized in choline chloride/urea deep eutectic solvent. Substituted 2-mercapto-4(3H)-quinazolinones were synthesized from anthranilic acid or 5-iodoanthranilic acid and appropriate isothiocyanates in good to excellent yields. Isolation of final product was easy and required no further purification. Synthesis of these compounds was rapid, selective, and catalyst free, while preparation of deep eutectic solvent was easy, components are readily available, cheap, and environmentally friendly. |
| Databáze: | OpenAIRE |
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