T cell receptor V beta expression by mucosal T cells
| Autor: | Jo Spencer, Thomas T. MacDonald, M Y Choy |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.drug_class Receptors Antigen T-Cell alpha-beta T-Lymphocytes Immunoglobulin Variable Region Biology Monoclonal antibody Pathology and Forensic Medicine Crohn Disease Intestinal mucosa Cell surface receptor Internal medicine medicine Superantigen Humans Intestinal Mucosa Child Beta (finance) Lamina propria T-cell receptor General Medicine T lymphocyte Middle Aged Celiac Disease medicine.anatomical_structure Endocrinology Child Preschool Research Article |
| Zdroj: | Journal of Clinical Pathology. 44:915-918 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.44.11.915 |
| Popis: | Immunohistochemistry with monoclonal antibodies to the T cell receptor V beta regions 5, 6, 8 and 12 was used to determine whether normal intestinal lymphocytes that are potentially exposed to many bacterially derived superantigens show any preferential expression of particular V beta regions compared with the blood. No difference between V beta expression in the mucosa and the blood was observed, suggesting that they share a common pool of alpha beta T cells and that there is no expansion of alpha beta T cells in response to bacterial "superantigens" in the gut. The T cell receptor V beta expressed by the activated T cells in the lamina propria of bowel from patients with Crohn's disease was also studied. There was no increase in V beta 8 expression in these cells, suggesting that the increase in V beta 8 observed in the blood and mesenteric nodes of patients with Crohn's disease is not of primary importance in the aetiology of the disease. Finally, V beta expression by mucosal T cells in coeliac disease was studied. There was no difference in V beta use by T cells in coeliac disease and those in the blood and normal jejunum. |
| Databáze: | OpenAIRE |
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