Maintenance of Germinal Center B Cells by Caspase-9 through Promotion of Apoptosis and Inhibition of Necroptosis
| Autor: | Jingting Zhang, Jin Wang, Min Chen, Srikanth Kodali |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Necroptosis
Immunology Naive B cell Apoptosis Article Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Immunology and Allergy Caspase B cell Mice Knockout Caspase-9 B-Lymphocytes biology Chemistry Germinal center Germinal Center Caspase 9 Cell biology medicine.anatomical_structure Immunization biology.protein 030215 immunology |
| Zdroj: | J Immunol |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | In response to T cell–dependent Ag encounter, naive B cells develop into germinal center (GC) B cells, which can further differentiate into Ab-secreting plasma cells or memory B cells. GC B cells are short lived and are prone to caspase-mediated apoptosis. However, how apoptotic caspases regulate GC B cell fate has not been fully characterized. In this study, we show that mice with B cell–specific knockout of caspase-9 had decreases in GC B cells and Ab production after immunization. Caspase-9–deficient B cells displayed defects in caspase-dependent apoptosis but increases in necroptosis signaling. Additional deletion of Ripk3 restored GC B cells and Ab production in mice with B cell–specific knockout of caspase-9. Our results indicate that caspase-9 plays an important role in the maintenance of Ab responses by promoting apoptosis and inhibiting necroptosis in B cells. |
| Databáze: | OpenAIRE |
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