Simulations of a Multipinhole SPECT Collimator for Clinical Dopamine Transporter (DAT) Imaging
| Autor: | Navid Zeraatkar, Timothy J. Fromme, Arda Konik, Jan De Beenhouwer, Kesava S. Kalluri, Joyeeta Mitra Mukherjee, Soumyanil Banerjee, Michael A. King |
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| Rok vydání: | 2018 |
| Předmět: |
Computer. Automation
Physics biology medicine.diagnostic_test Putamen Collimator Striatum Single-photon emission computed tomography Article Atomic and Molecular Physics and Optics Imaging phantom law.invention law Spect imaging biology.protein medicine Radiology Nuclear Medicine and imaging Instrumentation Image resolution Dopamine transporter Biomedical engineering |
| Zdroj: | IEEE Transactions on Radiation and Plasma Medical Sciences |
| ISSN: | 2469-7303 2469-7311 |
| DOI: | 10.1109/trpms.2018.2831208 |
| Popis: | SPECT imaging of the dopamine transporter (DAT) is used for diagnosis and monitoring progression of Parkinson's disease (PD), and differentiation of PD from other neurological disorders. The diagnosis is based on the DAT binding in the caudate and putamen structures in the striatum. We previously proposed a relatively inexpensive method to improve the detection and quantification of these structures for dual-head SPECT by replacing one of the fan-beam collimators with a specially designed multipinhole (MPH) collimator. In this paper, we developed a realistic model of the proposed MPH system using the GATE simulation package and verified the geometry with an analytic simulator. Point source projections from these simulations closely matched confirming the accuracy of the pinhole geometries. The reconstruction of a hot-rod phantom showed that 4.8-mm resolution is achievable. The reconstructions of the XCAT brain phantom showed clear separation of the putamen and caudate, which is expected to improve the quantification of DAT imaging and PD diagnosis. Using this GATE model, point spread functions modeling physical factors will be generated for use in reconstruction. Also, further improvements in geometry are being investigated to increase the sensitivity of this base system while maintaining a target spatial resolution of 4.5-5 mm. |
| Databáze: | OpenAIRE |
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