Cytolysin‐positive Enterococcus faecalis is not increased in patients with non‐alcoholic steatohepatitis

Autor:	Yi Duan, Bernd Schnabl, Muenevver Demir, Anna Martin, Sonja Lang
Rok vydání:	2020
Předmět:	medicine.medical_specialty Hepatology biology business.industry Fatty liver Alcoholic hepatitis Disease medicine.disease biology.organism_classification Gastroenterology Article Enterococcus faecalis Liver disease Internal medicine medicine bacteria Cytolysin Steatohepatitis business Dysbiosis
Zdroj:	Liver Int
ISSN:	1478-3231 1478-3223
DOI:	10.1111/liv.14377
Popis:	Several studies show associations between gut bacterial dysbiosis and chronic liver diseases, but causative mechanisms are largely unclear. We recently identified cytolysin, a bacterial exotoxin expressed and secreted by Enterococcus faecalis to cause liver damage in the setting of alcohol-related liver disease. Cytolysin was increased and highly correlated with liver disease severity and mortality in alcoholic hepatitis patients. In this study, we investigated if faecal cytolysin-positivity can be linked to non-alcoholic fatty liver disease, a highly prevalent disease where new biomarkers and treatment targets are urgently needed. In contrast to what we observed in alcoholic hepatitis, only seven out of 96 non-alcoholic fatty liver disease patients were cytolysin-positive, and these patients did not have increased liver disease activity compared with cytolysin-negative patients. These results indicate that the association of cytolysin carriage with worse clinical outcome might be specific for alcoholic hepatitis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aaa3f6ff001d9ec0e5179030e8efa4 https://doi.org/10.1111/liv.14377 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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