Separate MRI Quantification of Dispersed (Ferritin-like) and Aggregated (Hemosiderin-like) Storage Iron
| Autor: | Jens H. Jensen, Haiying Tang, Ed X. Wu, Truman R. Brown, Christina L. Tosti, Alvaro Nunez, Sujit Sheth, Kristi Hultman, Kamila U. Szulc, Daniel Kim, Srirama V. Swaminathan, Gary M. Brittenham |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Ferritins - metabolism
Adult Male Adolescent Ferritin iron Iron oxide chemistry.chemical_element Manganese Hemosiderin Image Interpretation Computer-Assisted - methods Sensitivity and Specificity Article Liver - anatomy and histology - metabolism chemistry.chemical_compound Young Adult Nuclear magnetic resonance Quantification Image Interpretation Computer-Assisted Iron overload Humans Magnetic Resonance Imaging - methods Radiology Nuclear Medicine and imaging In patient Tissue Distribution Ferritin Chromatography biology Human studies beta-Thalassemia Hemosiderin - metabolism Reproducibility of Results Image Enhancement Magnetic Resonance Imaging chemistry Liver Ferritins biology.protein Agarose Female Biomarkers MRI |
| Popis: | A new MRI method is proposed for separately quantifying the two principal forms of tissue storage (nonheme) iron: ferritin iron, a dispersed, soluble fraction that can be rapidly mobilized, and hemosiderin iron, an aggregated, insoluble fraction that serves as a long-term reserve. The method utilizes multiple spin echo sequences, exploiting the fact that aggregated iron can induce nonmonoexponential signal decay for multiple spin echo sequences. The method is validated in vitro for agarose phantoms, simulating dispersed iron with manganese chloride, and aggregated iron with iron oxide microspheres. To demonstrate feasibility for human studies, preliminary in vivo data from two healthy controls and six patients with transfusional iron overload are presented. For both phantoms and human subjects, conventional R 2 and R 2*relaxation rates are also measured in order to contrast the proposed method with established MRI iron quantification techniques. Quantification of dispersed (ferritin-like) iron may provide a new means of monitoring the risk of iron-induced toxicity in patients with iron overload and, together with quantification of aggregated (hemosiderin-like) iron, improve the accuracy of estimates for total storage iron. © 2010 Wiley-Liss, Inc. link_to_OA_fulltext |
| Databáze: | OpenAIRE |
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