Endogenous DNA Damage as a Source of Genomic Instability in Cancer
| Autor: | Anthony T. Tubbs, André Nussenzweig |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
DNA Replication
Transcriptional Activation 0301 basic medicine Genome instability Genetics DNA re-replication DNA Repair DNA repair DNA damage DNA replication Genotoxic Stress Biology Chromatin Genomic Instability Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology Neoplasms Mutation Humans DNA mismatch repair DNA Damage Epigenomics |
| Zdroj: | Cell. 168:644-656 |
| ISSN: | 0092-8674 |
| Popis: | Genome instability, defined as higher than normal rates of mutation, is a double-edged sword. As a source of genetic diversity and natural selection, mutations are beneficial for evolution. On the other hand, genomic instability can have catastrophic consequences for age-related diseases such as cancer. Mutations arise either from inactivation of DNA repair pathways or in a repair-competent background due to genotoxic stress from celluar processes such as transcription and replication that overwhelm high-fidelity DNA repair. Here, we review recent studies that shed light on endogenous sources of mutation and epigenomic features that promote genomic instability during cancer evolution. |
| Databáze: | OpenAIRE |
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