Aggressive multiple myeloma presenting as mesenteric panniculitis
| Autor: | Brian Otridge, Jason Goh, Padraic MacMathuna, Peter A. Dervan, Hugh Brady, Eamann Breatnach |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Abdominal pain Microcytic anemia Severity of Illness Index Panniculitis Peritoneal Diagnosis Differential Fatal Outcome medicine Humans Fat necrosis Fever of unknown origin Multiple myeloma Mesenteric Panniculitis Hepatology medicine.diagnostic_test business.industry Biopsy Needle Gastroenterology medicine.disease Erythrocyte sedimentation rate Disease Progression medicine.symptom business Panniculitis Multiple Myeloma Tomography X-Ray Computed |
| Zdroj: | The American journal of gastroenterology. 96(1) |
| ISSN: | 0002-9270 |
| Popis: | Mesenteric panniculitis is a rare disease of the bowel mesentery, characterized by tumor-like infiltration by chronic inflammatory cells, fat necrosis, and fibrosis. Reported cases cited clinical presentation ranging from abdominal pain to fever of unknown origin, the majority of which were idiopathic and associated with a benign prognosis. We report the case of a 43-yr-old male who presented with malaise, weight loss, microcytic anemia, and a high erythrocyte sedimentation rate. Radiographic and histological investigations revealed typical features of mesenteric panniculitis. Initial treatment with high-dose oral prednisolone led to rapid and complete resolution of symptomatology, radiographic, and laboratory anomalies. Within 6 months, the patient presented again with anemia, renal failure, and hypercalcemia. A diagnosis of IgA kappa chain myeloma was made. Despite chemotherapy and restoration of normocalcemia, he died from refractory pulmonary edema. This is the first report of a hematological malignancy initially presenting with features of mesenteric panniculitis culminating in an aggressive course and a fatal outcome. |
| Databáze: | OpenAIRE |
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