Non-Polio Enteroviruses from Acute Flaccid Paralysis Surveillance in Korea, 2012-2019
Autor: | June-Woo Lee, Chun Kang, Yong-Pyo Lee, Young Sil Yoon, Myung-Guk Han, Hye Jin Kim, Joong Hyun Bin, Sang Won Lee, Young Hoon Kim, Wooyoung Choi, Deog-Yong Lee, Hae Ji Kang |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Male Pediatrics medicine.medical_specialty Adolescent lcsh:QR1-502 medicine.disease_cause complex mixtures lcsh:Microbiology Article 03 medical and health sciences 0302 clinical medicine Virology Poliomyelitis eradication Republic of Korea medicine Humans 030212 general & internal medicine Child acute flaccid paralysis (AFP) poliovirus business.industry enterovirus Poliovirus Outbreak virus diseases Infant Neuromuscular Diseases Myelitis medicine.disease Poliomyelitis 030104 developmental biology Infectious Diseases Child Preschool Acute disseminated encephalomyelitis Epidemiological Monitoring Etiology Central Nervous System Viral Diseases surveillance Enterovirus Female business Meningitis |
Zdroj: | Viruses Viruses, Vol 13, Iss 411, p 411 (2021) Volume 13 Issue 3 |
ISSN: | 1999-4915 |
Popis: | The risk of polio importation and re-emergence persists since epidemic polio still occurs in some countries, and the resurgence of polio occurring almost 20 years after polio eradication was declared in Asia has been reported. We analyzed the results of acute flaccid paralysis (AFP) surveillance in Korea to assess the quality of AFP surveillance and understand the etiology of non-polio enterovirus (NPEV)-associated central nervous system diseases in a polio-free area. We investigated 637 AFP patients under 15 years of age whose cases were confirmed during 2012–2019 by virus isolation, real-time reverse transcription polymerase chain reaction, and VP1 gene sequencing. Among the 637 AFP cases, NPEV was detected in 213 (33.4%) patients, with the majority observed in EV-A71, with 54.9% of NPEV positives. EV-A71 has been shown to play a role as a major causative agent in most neurological diseases except for Guillain-Barré syndrome (GBS), acute disseminated encephalomyelitis (ADEM), and meningitis. This study provides information on the AFP surveillance situation in Korea and highlights the polio eradication stage in the monitoring and characterization of NPEV against the outbreak of neurological infectious diseases such as polio. |
Databáze: | OpenAIRE |
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