Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery
| Autor: | Abigail R. Hanby, Sarah L. Kidd, Thomas J. Osberger, Kim T. Mortensen, Nikolaj S. Troelsen, David R. Spring |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Natural product
010405 organic chemistry Computer science Fragment-based lead discovery Metals and Alloys General Chemistry Computational biology 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Fragment (logic) chemistry Materials Chemistry Ceramics and Composites |
| Zdroj: | Hanby, A R, Troelsen, N S, Osberger, T J, Kidd, S L, Mortensen, K T & Spring, D R 2020, ' Fsp 3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery ', Chemical Communications, vol. 56, 2280 . https://doi.org/10.1039/c9cc09796a |
| DOI: | 10.1039/c9cc09796a |
| Popis: | Herein, we describe the natural product inspired synthesis of 38 complex small molecules based upon 20 unique frameworks suitable for fragment-based screening. Utilising an efficient strategy, two key building block diastereomers were harnessed to generate novel, three-dimensional fragments which each possess numerous synthetically accessible fragment growth positions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|