Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study

Autor: Cecilia Augustsson, Louise Walther-Sturesson, Thomas Kander, Caroline Nilsson, Ulf Schött, Luukas Lilover
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Pharmacology
endothelial dysfunction
Protein S
vitamin K
chemistry.chemical_compound
Gas6
Matrix gla protein
Medicine
TX341-641
Cardiac and Cardiovascular Systems
Prospective Studies
Receptor
intensive care
Nutrition and Dietetics
biology
medicine.diagnostic_test
Vitamin K 1
Middle Aged
Blood Coagulation Factors
Coagulation
thrombin generation
Intercellular Signaling Peptides and Proteins
Administration
Intravenous
Female
Gla protein
Vitamin
Critical Care
Critical Illness
Article
Citric Acid
Proto-Oncogene Proteins
Intensive care
Humans
International Normalized Ratio
Aged
Prothrombin time
Anesthesiology and Intensive Care
Nutrition. Foods and food supply
GAS6
business.industry
Receptor Protein-Tyrosine Kinases
Axl receptor
prothrombin time
Axl Receptor Tyrosine Kinase
chemistry
biology.protein
Medicinal Chemistry
business
Food Science
Zdroj: Nutrients; 13(11), pp 1-12 (2021)
Nutrients
Volume 13
Issue 11
Nutrients, Vol 13, Iss 4101, p 4101 (2021)
ISSN: 2072-6643
Popis: Growth arrest-specific gene 6 protein (Gas6) is avitamin K-dependent tissue bound protein. Gas6 has been shown to promote growth and therapy resistance among different types of cancer as well as thromboembolism. The aim of this prospective screening study: ClinicalTrials.gov
Identifier: NTC3782025, was to evaluate the effects of intravenously administered vitamin K1 on Gas6 and its soluble (s)Axl receptor plasma levels in intensive care patients. Vitamin K1 was intravenously injected in non-warfarin treated patients with prolonged Owren prothrombin time international normalized ratio (PT-INR) >
1.2 and blood samples were retrieved before and 20–28 h after injection. Citrate plasma samples from 52 intensive care patients were analysed for different vitamin K dependent proteins. There was a significant, but small increase in median Gas6. Only one patient had a large increase in sAxl, but overall, no significant changes in sAxl Gas6 did not correlate to PT-INR, thrombin generation assay, coagulation factors II, VII, IX and X, but to protein S and decarboxylated matrix Gla protein (dp-ucMGP). In conclusion, there was a small increase in Gas6 over 20–28 h. The pathophysiology and clinical importance of this remains to be investigated. To verify a true vitamin K effect, improvement of Gas6 carboxylation defects needs to be studied.
Databáze: OpenAIRE
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