A prospective randomized double-blinded controlled study of ropivacaine 0.75% versus bupivacaine 0.5%–mepivacaine 2% for peribulbar anesthesia
| Autor: | Giuseppe A. Marraro, Giuseppe Magni, Marco Luchetti |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Bupivacaine
medicine.medical_specialty genetic structures Ropivacaine business.industry Local anesthetic medicine.drug_class medicine.medical_treatment Mepivacaine General Medicine Phacoemulsification Perioperative Cataract surgery eye diseases Surgery law.invention Anesthesiology and Pain Medicine Randomized controlled trial law Anesthesia medicine business medicine.drug |
| Zdroj: | Regional Anesthesia and Pain Medicine. 25:195-200 |
| ISSN: | 1098-7339 |
| DOI: | 10.1053/rapm.2000.0250195 |
| Popis: | Background and Objectives: Ropivacaine 1% has recently been used in clinical trials for peribulbar anesthesia. This study aims to compare the safety and the efficacy of ropivacaine 0.75% with that of a 1:1 mixture of bupivacaine 0.5% and mepivacaine 2% for peribulbar anesthesia. Methods: Two thousand patients undergoing peribulbar anesthesia for elective cataract phacoemulsification were prospectively studied over a 1-year period and randomly assigned to 1 of 2 groups according to the local anesthetic used. One thousand patients were administered peribulbar anesthesia with 9 mL of ropivacaine 0.75% plus 1 mL of hyaluronidase (group R), and 1,000 patients received peribulbar anesthesia with 4 mL of bupivacaine 0.5% plus 4 mL of mepivacaine 2% plus 1 mL of hyaluronidase plus 1 mL of sodium bicarbonate (group BM). Peribulbar anesthesia was always accomplished by the same physician by 2 injections of 5 mL each, with a 25-gauge 25-mm needle. Evaluation was performed by another physician blinded to the technique used and included assessment of pain on local anesthetic injection, ocular and eyelid akinesia, need for top-up injections, onset time and duration of anesthesia, intraoperative analgesia, duration of surgery, hemodynamic parameters, and incidence of perioperative complications. Results: A greater incidence of pain on injection was found in group BM (P |
| Databáze: | OpenAIRE |
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