Thymus-Marrow Immunocompetence III. The Requirement for Living Thymus Cells

Autor:	Henry N. Claman, E A Chaperon, J C Selner
Rok vydání:	1968
Předmět:	Mouse Thymus Transplantation Chemistry medicine.medical_treatment Cell Rat Thymus Biology Molecular biology General Biochemistry Genetics and Molecular Biology Thymectomy medicine.anatomical_structure Antigen Immunology Homologous chromosome medicine biology.protein Immunocompetence Antibody
Zdroj:	Experimental Biology and Medicine. 127:462-466
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-127-32715
Popis:	SummaryThe enhanced immunocompetence of transferred thymus-marrow cell combinations was demonstrated using the Jerne plaque-assay method. Suspensions containing both thymus and marrow cells produced more antibody to sheep erythrocytes when transferred to irradiated syngeneic hosts and stimulated with antigen than could be accounted for by the summation of thymus- or marrow-cell activities considered singly. Living homologous thymus cells were required, since the following materials were incapable of interacting with isologous marrow cells; sonicated or irradiated (53Or) mouse thymus cells or living rat thymus cells. The thymus of the host was not necessary for demonstrating thymus-marrow immunocompetence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6979a47bd9c84e610eebbf5e966b8d3 https://doi.org/10.3181/00379727-127-32715 Zobrazit plný text záznamu