Role of shear-wave and strain elastography to differentiate malignant vs benign subpleural lung lesions
| Autor: | Andrea Boccatonda, Valentina Susca, Francesco Cipollone, Cosima Schiavone, Sebastiano Cinalli, Gian Luca Primomo, Laura Martino, Felice Mucilli, Giulio Cocco, Velia Di Resta, Stefano Marinari |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Strain elastography Diagnostic methods Composite score Youden's J statistic Observational Study Malignancy Sensitivity and Specificity lung 03 medical and health sciences elastosonography 0302 clinical medicine Neoplasms medicine Humans cancer 030212 general & internal medicine Aged thorax Lung ultrasound business.industry Area under the curve General Medicine Middle Aged medicine.disease medicine.anatomical_structure ROC Curve Area Under Curve 030220 oncology & carcinogenesis Elasticity Imaging Techniques Female Tissue stiffness business Nuclear medicine Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Elastosonography is a non-invasive diagnostic method to evaluate tissue stiffness. The aim of our study was to demonstrate the applicability and efficacy of elastosonography to differentiate benign vs malignant subpleural lung lesions compared to clinical, radiological and histological findings. We performed both strain and shear wave velocity (SWV) elastosonography on subpleural lung lesions. Moreover, we elaborated a composite score called ”elasto index”. Fourteen patients, 10 males and 4 females were recruited. On strain elastography, 9 lesions showed a hard pattern (type 3), 3 lesions showed an intermediate pattern (type 2), and 2 lesions a soft pattern (type 1). All lesions showed a mean SWV value of 4.46 ± 2.37 m/second. The mean SWV for malignant lesions (n = 6) was 5.92 ± 2.8 m/second. The mean SWV for benign lesions (n = 8) was 3.36 ± 1.20 m/second. SWV shows an area under the curve (AUC) of 0.792, and the Youden index shows a value of 3.6 m/second. The ROC curve elaborated for the diagnosis of malignancy by strain elastography showed an AUC of 0.688. ROC curve for the diagnosis of malignancy by elasto index demonstrated an AUC of 0.802. SWV values obtained by ARFI elastosonographic method are higher in malignant lung lesions (mean SWV: 5.92 m/second) than in benign ones (mean SWV: 3.36); a composite score (elasto index) is characterized by better statistical significance for the differentiation of the lesions. |
| Databáze: | OpenAIRE |
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