Circulating miR-130 is a potential bio signature for early prognosis of acute myocardial infarction
| Autor: | Genshan Ma, Gaoliang Yan, Xiaodong Pan, Zhongpu Chen, Yanru He |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine medicine.medical_specialty Receiver operating characteristic biology business.industry 030204 cardiovascular system & hematology medicine.disease Pathogenesis Coronary artery disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Real-time polymerase chain reaction Internal medicine Troponin I biology.protein Cardiology Medicine Biomarker (medicine) Creatine kinase Original Article Myocardial infarction cardiovascular diseases business |
| Zdroj: | J Thorac Dis |
| Popis: | BACKGROUND: As distinctive leading reasons of death globally, acute myocardial infarction (AMI). Accounts for major death ratio, caused by coronary artery disease (CAD). Its diagnosis relies on the presenting clinical symptoms, electrocardiograms (ECGs), and levels of circulating biomarkers. Recent studies have implicated microRNAs (miRNAs) in the pathogenesis of many diseases, including AMI. The present study inquire into feature value of miR-130 in AMI patients. METHODS: levels of expression of miR-130 in patient plasma, considered through simultaneous quantitative polymerase chain reaction (qRT-PCR). The method used for determining Plasma cardiac troponin I (cTnI) & creatine kinase-MB(CK-MB) degree set on by enzyme-linked immunosorbent assay (ELISA). The diagnostic value of miR-130 was measured using a receiver operating characteristic (ROC) curve. RESULTS: Plasma miR-130, cTnI, and CK-MB levels exist remarkably inflated in the AMI classification in comparison with control category (P |
| Databáze: | OpenAIRE |
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