Candidatus Mycoplasma haemohominis in Human, Japan
| Autor: | Ryo Yanai, Tsuyoshi Nakamaki, Takahiro Takuma, Norimichi Hattori, Yoshihito Niki, Tsuyoshi Sekizuka, Sho Ishii, Hiroyuki Watanabe, Makoto Kuroda, Takayoshi Ito, T. Tokunaga, Harutaka Katano, Nana Arai, Hideki Hasegawa, Junichi Eguchi, Yoko Miura, Norihiro Nomura, Takaji Wakita |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Microbiology (medical) Epidemiology medicine.drug_class lcsh:Medicine medicine.disease_cause Candidatus Mycoplasma haemohominis in Human Japan DNA gyrase Deep sequencing lcsh:Infectious and parasitic diseases hemophagocytic syndrome Mycoplasma Japan Moxifloxacin Levofloxacin medicine Humans lcsh:RC109-216 Mycoplasma Infections bacteria Skin metagenomics Candidatus Mycoplasma haemohominis business.industry Pruritus lcsh:R High-Throughput Nucleotide Sequencing hemoplasma Minocycline biochemical phenomena metabolism and nutrition Quinolone Candidatus M. haemohominis Virology Microscopy Electron Infectious Diseases Erythema Synopsis Candidatus human infection business medicine.drug |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 26, Iss 1, Pp 11-19 (2020) |
| ISSN: | 1080-6059 1080-6040 |
| DOI: | 10.3201/eid2601.190983 |
| Popis: | Hemotropic mycoplasmas are common pathogens in animals, but it remains unclear what role these pathogens play in human infections. We report clinical and biologic characterization of Candidatus Mycoplasma haemohominis infection in a 42-year-old man in Japan. The patient had severe hemophagocytic syndrome 1 month after an accidental needlestick injury. Metagenomic deep sequencing identified Candidatus M. haemohominis and determined its draft genome for an isolate from serum of the patient. A high copy number of the Candidatus M. haemohominis genome was detected in serum and bone marrow samples. Electron microscopy examination showed morphologic characteristics of Candidatus M. haemohominis. Levofloxacin monotherapy induced resistance caused by a gyrase A gene mutation in the quinolone resistance–determining region, but a combination treatment with moxifloxacin and minocycline was effective. We identified Candidatus M. haemohominis in a patient who had life-threatening symptoms related to multiple organ infection. Human infection with this mycoplasma might occur more frequently than has been generally recognized. |
| Databáze: | OpenAIRE |
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