Naphthoquinone Derivatives with Anti-Inflammatory Activity from Mangrove-Derived Endophytic Fungus Talaromyces sp. SK-S009
| Autor: | Hongju Liu, Changqun Li, Tingting You, Zhigang She, Chong Yan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
Lipopolysaccharide medicine.drug_class Pharmaceutical Science Nitric Oxide Synthase Type II Nitric Oxide Real-Time Polymerase Chain Reaction 01 natural sciences Anti-inflammatory Article Analytical Chemistry Nitric oxide lcsh:QD241-441 chemistry.chemical_compound Mice lcsh:Organic chemistry Drug Discovery talaromyces sp medicine Animals Physical and Theoretical Chemistry marine fungus IC50 anti-inflammatory biology Molecular Structure 010405 organic chemistry Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Interleukin Molecular biology Naphthoquinone 0104 chemical sciences Nitric oxide synthase 010404 medicinal & biomolecular chemistry RAW 264.7 Cells chemistry Talaromyces Chemistry (miscellaneous) Cyclooxygenase 2 biology.protein Molecular Medicine Tumor necrosis factor alpha Talaromyces sp 1 4-naphthoquinones Inflammation Mediators Naphthoquinones |
| Zdroj: | Molecules Molecules, Vol 25, Iss 3, p 576 (2020) Volume 25 Issue 3 |
| ISSN: | 1420-3049 |
| Popis: | Twelve 1, 4-naphthoquinone derivatives, including two new (1 and 2) and 10 known (3&ndash 12), were obtained from endophytic fungus Talaromyces sp. SK-S009 isolated from the fruit of Kandelia obovata. All structures were identified through extensive analysis of the nuclear magnetic resonance (NMR), mass spectrometry (MS) and circular dichroism (CD), as well as by comparison with literature data. These compounds significantly inhibited the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in the murine macrophage cell line (RAW 264.7 cells). The half maximal inhibitory concentration (IC50) values, except for compound 2, were lower than that of indomethacin (26.3 &mu M). Compound 9 inhibited the LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expressions in RAW 264.7 macrophages. Additionally, compound 9 reduced the mRNA levels of pro-inflammatory factors interleukin (IL)1&beta IL-6, and tumor necrosis factor (TNF)-&alpha The results of this study demonstrated that these 1, 4-naphthoquinone derivatives can inhibit LPS-induced inflammation. |
| Databáze: | OpenAIRE |
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