Evidence for Host-Bacterial Co-evolution via Genome Sequence Analysis of 480 Thai Mycobacterium tuberculosis Lineage 1 Isolates
| Autor: | Sissades Tongsima, Supalert Nedsuwan, Taane G. Clark, Boonchai Chaiyasirinroje, Pravech Ajawatanawong, Norio Yamada, Prasit Palittapongarnpim, Panawun Palittapongarnpim, Martin L. Hibberd, Wuthiwat Ruengchai, Surakameth Mahasirimongkol, Katsushi Tokunaga, Licht Toyo-oka, Jody Phelan, Nat Smittipat, Areeya Disratthakit, Worarat Imasanguan, Pacharee Kantipong, Hideki Yanai, Julian Parkhill, Wasna Viratyosin, Tada Juthayothin, Jiraporn Wongyai |
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| Přispěvatelé: | Toyo-Oka, Licht [0000-0002-9738-2441], Phelan, Jody [0000-0001-8323-7019], Parkhill, Julian [0000-0002-7069-5958], Clark, Taane G [0000-0001-8985-9265], Tongsima, Sissades [0000-0002-1491-1839], Apollo - University of Cambridge Repository |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Tuberculosis Lineage (evolution) lcsh:Medicine Article Mycobacterium tuberculosis Evolution Molecular 03 medical and health sciences Monophyly medicine Humans lcsh:Science Clade Whole genome sequencing Multidisciplinary biology Phylogenetic tree Whole Genome Sequencing lcsh:R biology.organism_classification medicine.disease Thailand 3. Good health 030104 developmental biology Evolutionary biology Host-Pathogen Interactions lcsh:Q Female Genome Bacterial Founder effect |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Tuberculosis presents a global health challenge. Mycobacterium tuberculosis is divided into several lineages, each with a different geographical distribution. M. tuberculosis lineage 1 (L1) is common in the high-burden areas in East Africa and Southeast Asia. Although the founder effect contributes significantly to the phylogeographic profile, co-evolution between the host and M. tuberculosis may also play a role. Here, we reported the genomic analysis of 480 L1 isolates from patients in northern Thailand. The studied bacterial population was genetically diverse, allowing the identification of a total of 18 sublineages distributed into three major clades. The majority of isolates belonged to L1.1 followed by L1.2.1 and L1.2.2. Comparison of the single nucleotide variant (SNV) phylogenetic tree and the clades defined by spoligotyping revealed some monophyletic clades representing EAI2_MNL, EAI2_NTM and EAI6_BGD1 spoligotypes. Our work demonstrates that ambiguity in spoligotype assignment could be partially resolved if the entire DR region is investigated. Using the information to map L1 diversity across Southeast Asia highlighted differences in the dominant strain-types in each individual country, despite extensive interactions between populations over time. This finding supported the hypothesis that there is co-evolution between the bacteria and the host, and have implications for tuberculosis disease control. |
| Databáze: | OpenAIRE |
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