Buflomedll: Three Month Intravenous Safety Evaluation in Rats
| Autor: | J. W. Kesterson, S. Tekeli, I. A. Heyman, P. K. Cusick, F. L. Fort, J. P. Lewkowski |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Pyrrolidines Ataxia Dose Vasodilator Agents Health Toxicology and Mutagenesis Decreased body weight Toxicology Body weight chemistry.chemical_compound Sex Factors Buflomedil medicine Jerking movements Animals Dosing Pharmacology Chemical Health and Safety Dose-Response Relationship Drug business.industry Body Weight Public Health Environmental and Occupational Health Rats Inbred Strains Organ Size General Medicine Rats Dyspnea chemistry Anesthesia Injections Intravenous Female medicine.symptom business Serum chemistry |
| Zdroj: | Drug and Chemical Toxicology. 5:401-414 |
| ISSN: | 1525-6014 0148-0545 |
| DOI: | 10.3109/01480548208993192 |
| Popis: | Buflomedil was administered intravenously to rats at dosages of 1, 4, 12 or 30 mg/kg/day for up to three months. The no-adverse-effect dosage was considered to be 12 mg/kg/day. At 30 mg/kg/day several deaths and clinical signs, including ataxia, decreased activity, dyspnea and jerking movements after dosing, were observed. These were considered to result from the acute, exaggerated pharmacologic effects of buflomedil. Body weight gain and food consumption were decreased after six weeks in males at 30 mg/kg/day. Increases in the relative weights of the kidneys, brain and testes of males at 30 mg/kg/day were correlated with decreased body weight gain in this group. There were no effects on hematology or serum chemistry parameters, and no morphologic changes were found. |
| Databáze: | OpenAIRE |
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