Angiopoietin-2 primes infection-induced preterm delivery

Autor: Demetrios Kassanos, N Evangelinakis, Charalambos Chrelias, Antigone Kotsaki, Charalampos Siristatidis, Electra N. Polyzou, Aikaterini Pistiki, Evangelos J. Giamarellos-Bourboulis, Emmanuel Salamalekis
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Lipopolysaccharides
Male
Embryology
Necrosis
Mouse
medicine.medical_treatment
Placenta
chemistry.chemical_compound
Labor and Delivery
Mice
Pregnancy
Prospective Studies
Immune Response
Evans Blue
Multidisciplinary
Gestational age
Obstetrics and Gynecology
Animal Models
medicine.anatomical_structure
cardiovascular system
Premature Birth
Medicine
Female
medicine.symptom
Perfusion
hormones
hormone substitutes
and hormone antagonists
Research Article
Clinical Research Design
Science
Intraperitoneal injection
Gestational Age
Andrology
Angiopoietin-2
Model Organisms
medicine
Animals
Humans
Management of High-Risk Pregnancies
Biology
Fetus
business.industry
Preterm Labor
Tumor Necrosis Factor-alpha
medicine.disease
Mice
Inbred C57BL
Pregnancy Trimester
First
chemistry
Immunology
Women's Health
Clinical Immunology
business
Developmental Biology
Zdroj: PLoS ONE, Vol 9, Iss 1, p e86523 (2014)
PLoS ONE
ISSN: 1932-6203
Popis: Current knowledge on the participation of angiopoietin-2 (Ang-2) in the inflammatory process and on the importance of bacterial endotoxins (LPS) in the induction of preterm delivery (PTD) led us to investigate the role of Ang-2/LPS interplay in the pathogenesis of PTD. At a first stage, Ang-2 was measured at the end of the first trimester of pregnancy in the serum of 50 women who delivered prematurely; of 88 women well-matched for age and parity who delivered full-term; and of 20 non-pregnant healthy women. Ang-2 was greater in pregnant than in non-pregnant women. The time until delivery was shorter among those with Ang-2 greater than 4 ng/ml (odds ratio for delivery until week 34; p: 0.040). To further investigate the role of Ang-2 for PTD, an experimental model of PTD induced by the intraperitoneal injection of LPS in mice was used. Ang-2 was administered intraperitoneally before LPS on day 14 of pregnancy. When Ang-2 was administered before the LPS diluent, all mice delivered full-term. However, administration of Ang-2 prior LPS accelerated further the time until delivery. Sacrifice experiments showed that the effect of Ang-2 was accompanied by decrease of the penetration of Evans Blue in the embryos and by increase of its penetration in maternal tissues. In parallel, the concentration of tumour necrosis factor-alpha in the maternal circulation, in fetal tissues and in the placentas was significantly decreased. Results indicate that Ang-2 accelerated the phenomena of PTD induced by LPS. This is related with deprivation of fetal perfusion.
Databáze: OpenAIRE
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