Relationship between Plasma Antioxidants and Thyroid Hormones in Chronic Obstructive Pulmonary Disease
| Autor: | Annarita Gaballo, Alfredo Pontecorvi, Salvatore Valente, P Gigliotti, G.P. Littarru, C Di Segni, Giuseppe Maria Corbo, Andrea Silvestrini, Antonio Mancini, Elisabetta Meucci, Sebastiano Raimondo |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Thyroid Hormones medicine.medical_specialty Systemic disease Ubiquinone Endocrinology Diabetes and Metabolism Thyrotropin medicine.disease_cause Antioxidants Pulmonary Disease Chronic Obstructive chemistry.chemical_compound Endocrinology Hypothyroidism Internal medicine Prevalence Internal Medicine medicine Humans Lung Aged Aged 80 and over Coenzyme Q10 COPD Triiodothyronine Cholesterol business.industry Thyroid General Medicine Middle Aged medicine.disease respiratory tract diseases Oxidative Stress Thyroxine medicine.anatomical_structure Italy chemistry Regression Analysis Female business Oxidative stress |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 120:623-628 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0032-1323808 |
| Popis: | BACKGROUND: A low-T₃ syndrome is observed in chronic diseases, but its treatment is still debated. Chronic obstructive pulmonary disease (COPD) has not been conclusively studied under this aspect. COPD is a complex condition, which cannot be considered a lung-related disorder, but rather a systemic disease also associated to increased oxidative stress. We evaluated thyroid hormones and antioxidant systems, the lipophilic Coenzyme Q10 (CoQ₁₀) and total antioxidant capacity (TAC) in COPD patients to reveal the presence of a low-T₃ syndrome in COPD and investigate the correlation between thyroid hormones, lung function parameters and antioxidants. METHODS: We studied: 32 COPD patients and 45 controls, evaluating thyrotropin (TSH), free-triiodotyronine (fT₃), free-tetraiodotyronine (fT₄), CoQ₁₀ (also corrected for cholesterol) and TAC. CoQ₁₀ was assayed by HPLC; TAC by the metmyoglobin-ABTS method and expressed as latency time (LAG) in radical species appearance. RESULTS: We found significantly lower LAG values, fT₃ and fT₄ levels and significantly higher TSH in COPD patients vs. controls. LAG values significantly correlated with fT₃ concentration. 12 out of 32 patients exhibited fT₃ levels lower than normal range. So we divided COPD patients in 2 groups on the basis of the fT₃ concentration (normal fT₃ COPD and low fT₃ COPD). We observed lower LAG values in normal fT₃-COPD, compared to healthy subjects, with a further significant reduction in low fT₃-COPD patients. Moreover higher TSH concentration was present in normal fT₃-COPD, compared to healthy subjects, with a further significant increase in low fT₃-COPD patients. CoQ₁₀/cholesterol ratio was higher in low fT₃-COPD vs. normal fT₃-COPD, with a nearly significant difference. CONCLUSIONS: These data seem to indicate an increased oxidative stress in low fT₃-COPD and a role of fT₃ in modulating antioxidant systems. However low fT₃ levels are joined to metabolic indexes of true hypothyroidism, suggesting that elevated CoQ₁₀ expresses a reduced tissue utilization. These data might suggest the need of thyroid replacement therapy in such a condition. |
| Databáze: | OpenAIRE |
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