Achievements and challenges in the use of metronomics for the treatment of breast cancer

Autor: Leandro Ernesto Mainetti, Viviana R. Rozados, María J. Rico, O. Graciela Scharovsky, Herman A. Perroud
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Antineoplastic Agents
Breast Neoplasms
Medicina Clínica
ACHIEVEMENTS AND CHALLENGES
Malignancy
Biochemistry
DRUG REPOSITIONING
Oncología
Metastasis
03 medical and health sciences
0302 clinical medicine
Breast cancer
BREAST CANCER
Antineoplastic Combined Chemotherapy Protocols
purl.org/becyt/ford/3.2 [https]
medicine
Humans
Intensive care medicine
Pharmacology
Low toxicity
business.industry
Therapeutic effect
Drug Repositioning
Cancer
TRIPLE NEGATIVE
medicine.disease
Metronomic Chemotherapy
METRONOMIC CHEMOTHERAPY
Drug repositioning
Treatment Outcome
030104 developmental biology
030220 oncology & carcinogenesis
Administration
Metronomic
PRECLINICAL-CLINICAL
Neoplastic Stem Cells
Female
purl.org/becyt/ford/3 [https]
business
Zdroj: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR
Popis: Two interesting therapeutic proposals for cancer treatment emerged at the beginning of the 21st century. The first one was metronomic chemotherapy, which refers to the chronic administration of chemotherapeutic agents, in low doses, without extended drug-free periods. Then, the idea of drug repositioning in oncology, the use of well-known drugs that were created for other uses to be utilized in oncology, gained strength. Shortly after, the two strategies were merged in one, named metronomics. Both approaches share several features which make metronomics an appealing choice for cancer treatment: use of known and approved drugs, thus diminishing the time necessary to enter to the clinic, therapeutic effect, low toxicity, oral administration, better life quality, low costs because of the use of, generally, out of patent drugs, possibility of use, even in countries with very low economic resources.Many chemotherapy and repurposed drugs were tested with metronomics approaches for the treatment of mammary cancer, the most common malignancy in women worldwide, leading to high rates of mortality. The wide range of therapeutic models studied, paralleled the wide range of responses obtained, like tumor growth and metastasis inhibition, overall survival increase, lack of toxicity, better life quality, among others. The accomplishments reached, and the challenges faced by researchers, are discussed. Fil: Scharovsky, Olga Graciela. Universidad Nacional de Rosario. Facultad de Ciencias Medicas. Instituto de Genetica Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Rico, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Medicas. Instituto de Genetica Experimental; Argentina Fil: Mainetti, Leandro Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Medicas. Instituto de Genetica Experimental; Argentina Fil: Perroud, Herman Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Medicas. Instituto de Genetica Experimental; Argentina Fil: Rozados, Viviana Rosa. Universidad Nacional de Rosario. Facultad de Ciencias Medicas. Instituto de Genetica Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Databáze: OpenAIRE
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