Allium cepa Linn juice protect against alterations in reproductive functions induced by maternal dexamethsone treatment during lactation in male offspring of Wistar rats
| Autor: | O T Kunle-Alabi, S.O. Jeje, Yinusa Raji, O O Akindele, L.O. Adegbite |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Offspring Veterinary medicine Biology medicine.disease_cause Toxicology Article Dexamethasone Andrology Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lactation medicine lcsh:Social sciences (General) lcsh:Science (General) Multidisciplinary Allium cepa L food and beverages Health sciences Glutathione Malondialdehyde Free radical scavenger 030104 developmental biology medicine.anatomical_structure chemistry Reproductive axis Oxidative stress biology.protein lcsh:H1-99 030217 neurology & neurosurgery medicine.drug lcsh:Q1-390 |
| Zdroj: | Heliyon Heliyon, Vol 6, Iss 5, Pp e03872-(2020) |
| ISSN: | 2405-8440 |
| Popis: | Treatment with dams with dexamethasone during lactation has been reported to induce oxidative stress in the testis of the offspring. Allium cepa L (Red Onion) is known to be a potent free radical scavenger. The protective role of Allium cepa against oxidative stress induced in testis following treatment with dexamehasone during lactation in Wistar rats was assessed. Twenty female rats were assigned into four groups (n = 5) during lactation and they were treated as follows: Group 1 serve as Control (distilled water), Group 2, 3, and four were admistered dexamethasone (60 μg/kg), Allium cepa (5 ml/kg) and dexamethasone + Allium cepa respectively. Testicular descent, pubertal age, sperm quality indices, and serum hormonal profile were assessed as indices of reproductive function. Testicular malondialdehyde (MDA) reduced glutathione (GSH) as well as superoxide dismutase (SOD) and catalase activities were assessed as measures of oxidative stress. Results obtained showed that dexamethasone caused significant (P < 0.05) reduction in testes weights, indices of sperm quality, serum testosterone, FSH, LH levels and testicular antioxidant enzyme activities. There was significant delay (P < 0.05) in days of testes descent, preputial separation and increase in testicular MDA. However, maternal treatment with Allium cepa Linn juice significantly (P < 0.05) improved both indices of reproductive function and testicular antioxidant enzymes. These findings suggest that Allium cepa Linn has a protective effect against testicular oxidative stress and reproductive dysfunction following treatment of dams with dexamethasone during lactation. Toxicology; Veterinary medicine; Health sciences; Allium cepa L; Dexamethasone; Oxidative stress; Reproductive axis. |
| Databáze: | OpenAIRE |
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