Triterpenoid Contents and Anti-Inflammatory Properties of the Methanol Extracts of Ligustrum Species Leaves
| Autor: | You-Cheng Hseu, Chi-Rei Wu, Li-Wei Lin, Yung-Ta Lin, Jin-Cherng Lien, Hui Ching |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Chronic bronchitis
Ligustrum Anti-Inflammatory Agents Pharmaceutical Science Ligustrum pricei Article Analytical Chemistry Capillary Permeability lcsh:QD241-441 Mice chemistry.chemical_compound lcsh:Organic chemistry Ursolic acid Betulinic acid Drug Discovery Animals Physical and Theoretical Chemistry analgesic activity Oleanolic acid Ligustrum lucidum Chromatography High Pressure Liquid Lupeol Ligustrum plants biology Traditional medicine Plant Extracts Methanol Organic Chemistry Privet anti-inflammatory activity triterpenoids biology.organism_classification Triterpenes Rats Plant Leaves chemistry Chemistry (miscellaneous) Molecular Medicine |
| Zdroj: | Molecules, Vol 16, Iss 1, Pp 1-15 (2010) Molecules Molecules; Volume 16; Issue 1; Pages: 1-15 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules16010001 |
| Popis: | Ligustrum (privet) plants are used by Chinese physicians to prevent and cure hepatitis and chronic bronchitis. Three common Ligustrum plant spp., namely Ligustrum lucidum Ait. (LL), L. pricei Hayata (LP) and L. sinensis Lour. (LS) were collected to assess their analgesic/anti-inflammatory properties on chemical-induced nociception and carrageenan-induced inflammation in rodents. The methanol extracts from Ligustrum plants leaves effectively inhibited nociceptive responses induced by 1% acetic acid and 1% formalin. LP and LL reduced the edema induced by 1% carrageenan. LP exhibited the best potency of the Ligustrum plants. Furthermore, LP reduced the abdominal Evan’s blue extravasations caused by lipopolysaccharide, lipoteichoic acid, autocrines and sodium nitroprusside. The triterpenoid content of the three Ligustrum spp. was measured by high performance liquid chromatography using a photodiode array detector. LP contained the highest content of amyrin, betulinic acid and lupeol. LL had the highest content of oleanolic acid and ursolic acid. The various degrees of analgesic/anti-inflammatory effects among three Ligustrum plants may be related to their different triterpenoid contents. LP is a potential analgesic and anti-inflammatory Ligustrum plant. The effects of LP are partially related to the inhibition of cyclooxygenase-2 activity and a decrease in microvascular permeability via the actions of autocrines and kinins. |
| Databáze: | OpenAIRE |
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