Nonalcoholic Fatty Liver Disease
| Autor: | Ronald Borra, Markku Komu, Riikka Lautamäki, Sakari Salo, Kirsti Dean, Riitta Parkkola, Pirjo Nuutila |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
In vivo magnetic resonance spectroscopy
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Gastroenterology Sensitivity and Specificity STEATOHEPATITIS Insulin resistance Internal medicine Diabetes mellitus Nonalcoholic fatty liver disease medicine Image Processing Computer-Assisted IRON OVERLOAD Humans STEATOSIS Radiology Nuclear Medicine and imaging Prospective cohort study Aged GENERAL-POPULATION INSULIN-RESISTANCE medicine.diagnostic_test business.industry GRADIENT-ECHO Fatty liver Magnetic resonance imaging Middle Aged Reference Standards MAGNETIC-RESONANCE-SPECTROSCOPY QUANTIFICATION medicine.disease Image Enhancement Magnetic Resonance Imaging Fatty Liver Diabetes Mellitus Type 2 Liver HEPATIC TRIGLYCERIDE CONTENT RISK-FACTORS Female Steatohepatitis business Nuclear medicine Software |
| Zdroj: | Radiology, 250(1), 130-136. RADIOLOGICAL SOC NORTH AMERICA |
| ISSN: | 0033-8419 |
| Popis: | To evaluate in-phase and out-of-phase magnetic resonance (MR) imaging in the estimation of liver fat content (LFC) in patients with nonalcoholic fatty liver disease (NAFLD), with hydrogen ((1)H) MR spectroscopy as the reference standard.Written informed consent was obtained from all subjects, and the local ethics committee approved this prospective study protocol. A total of 33 patients with type 2 diabetes mellitus who were at high risk for NAFLD (23 men, 10 women; overall mean age, 62.8 years +/- 8.3 [standard deviation]; age range, 48-77 years) underwent 1.5-T MR imaging with (1)H MR spectroscopy and in-phase and out-of-phase imaging of the liver. Three fat indexes were calculated from the signal intensity (SI) measured on the images. Two radiologists independently graded SI changes between in-phase and out-of-phase images by means of visual inspection. The Pearson correlation coefficient was used to study the relationship between the obtained parameters of SI change and LFC measured with (1)H MR spectroscopy.Fat indexes calculated from in-phase and out-of-phase images correlated linearly with LFC measured with (1)H MR spectroscopy (P.001, r = 0.94-0.96) and were superior (P = .004) to visual estimates (P.001, r = 0.88). The simple difference in SI between in-phase and out-of-phase images was used to calculate the fat index. An intercept of the regression line with the x-axis was observed at 5.1%, discriminating between normal and elevated LFC with high sensitivity (95%) and specificity (98%).In-phase and out-of-phase imaging can be used to rapidly estimate the LFC in patients with NAFLD. The cutoff value of 5.1% enables objective rapid and reliable discrimination of normal LFC from elevated LFC. |
| Databáze: | OpenAIRE |
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