Case report of rhabdoid colon cancer and review of literature
| Autor: | Nathan Bahary, Dulabh Monga, Gurleen Pasricha, Aatur D. Singhi, Aparna Kalyan |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Chemotherapy Pathology medicine.medical_specialty business.industry Colorectal cancer medicine.medical_treatment Gastroenterology Cancer Disease medicine.disease Primary tumor Cecum medicine.anatomical_structure Oncology Antineoplastic Combined Chemotherapy Protocols Colonic Neoplasms medicine Effective treatment Humans Female Colonic adenocarcinoma business Rhabdoid Tumor |
| Zdroj: | Clinical colorectal cancer. 14(1) |
| ISSN: | 1938-0674 |
| Popis: | Introduction Rhabdoid colon cancer is an extremely rare tumor type with only a few cases in the literature. It is a highly aggressive tumor with no proven effective treatment. The hallmark histologic findings of rhabdoid tumors are an eccentrically located and large nucleus, prominent nucleoli, and cytosolic aggregates of intermediate filaments.Wedescribe a case of a rhabdoid tumor arising at the cecum in a 31-year-old woman. Her tumor lacked the classic colonic adenocarcinoma immunoprofile, yet grossly originated within the cecum. Molecular sequencing identified KRASp.Q61H and TP53p.R273H mutations. Despite resection of her primary tumor (at which time no metastatic disease was noted) and subsequent chemotherapy, metastatic disease appeared and she died 18 weeks later. Her case underscores the need for better understanding of the aggressive biological characteristics of this rare tumor to offer better insight into molecularly directed treatment paradigms for rhabdoid tumors. |
| Databáze: | OpenAIRE |
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