In vitro biotransformation of thiazopyr by rat liver microsomes: oxidative cleavage of a carboxylic methylester by monooxygenases
| Autor: | P. C. C. Feng, R. T. Solsten |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Piperonyl butoxide Chromatography Gas Health Toxicology and Mutagenesis Metabolite Carboxylic acid Carboxylic Acids In Vitro Techniques Toxicology Biochemistry Niacin Mass Spectrometry Mixed Function Oxygenases Rats Sprague-Dawley chemistry.chemical_compound Biotransformation Species Specificity Animals Chromatography High Pressure Liquid Pharmacology chemistry.chemical_classification biology Herbicides General Medicine Metabolism Monooxygenase biology.organism_classification Rats Thiazoles Microsoma chemistry Microsome Microsomes Liver Oxidation-Reduction |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 24(8) |
| ISSN: | 0049-8254 |
| Popis: | 1. Thiazopyr was metabolized by liver microsomes from male Sprague-Dawley rats to a previously unidentified metabolite. 2. The new metabolite was identified by coelution with an authentic standard in hplc and by electrospray lc/ms as the corresponding carboxylic acid. 3. Formation of the carboxylic acid metabolite was inhibited in the presence of mono-oxygenase inhibitors including piperonyl butoxide, 1-aminobenzotriazole, metyrapone and tetcyclacis. 4. Transformation of thiazopyr to its carboxylic acid by rat liver microsomes is mediated by mono-oxygenases and not hydrolases. |
| Databáze: | OpenAIRE |
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