Association between hsCRP Levels, Glycemic Control and Total Interatrial Conduction Time in Patients with Type 2 Diabetes Mellitus
| Autor: | Bhisma Murti, Isyana Miranti K, Trisulo Wasyanto |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
HbA1c endocrine system diseases business.industry lcsh:R lcsh:Medicine nutritional and metabolic diseases Type 2 Diabetes Mellitus Atrial fibrillation Venous blood Type 2 diabetes medicine.disease Systemic inflammation hsCRP Endocrinology Tissue Doppler echocardiography Internal medicine glycemic control medicine Cardiology Population study medicine.symptom business total interatrial conduction time Glycemic |
| Zdroj: | Indonesian Journal of Medicine, Vol 1, Iss 1, Pp 58-70 (2016) BASE-Bielefeld Academic Search Engine |
| DOI: | 10.26911/theijmed.2016.01.01.08 |
| Popis: | Background : Type 2 Diabetes Mellitus (T2DM) represents one of the most important risk factors for atrial fibrillation (AF). Numerous studies have shown that T2DM and poor glycemic control reflected by glycated hemoglobin A1c (HbA1c) levels are independently associated with new onset AF. Recent experimental studies reported that the increased susceptibility to AF in the diabetic patients was presumably due to the slowing of conduction associated with increased interstitial fibrosis. Systemic inflammation cam play role in the development of atrial fibrillation. High-sensitivity C-reactive protein (hsCRP) is an inflammatory biomarker that independently predicts the cardiovascular risk. This study aimed to determine the association between hsCRP level and glycemic control with total interatrial conduction time in T2DM patients. Subjects and Methods: This was an analytic study with cross-sectional design. A total of samples were 41 patients with T2DM. Peripheral venous blood samples to measure hsCRP and HbA1c were drawn in all study population. The total interatrial conduction time was measured by tissue Doppler echocardiography. Multivariate analysis was performed using multiple regression analysis. P < 0,050 was considered to indicate a statistically significant difference. Results : The high-sensitivity C-reactive protein level was higher in the T2DM patients with HbA1c≥7% than in the T2DM patients with HbA1c |
| Databáze: | OpenAIRE |
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