The Diagnostic Challenge of Acquired Thrombotic Thrombocytopenic Purpura in Children: Case Report and Review of the Literature
| Autor: | Elise Schapkaitz, Tanya Marié Schickerling |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Erythrocytes Clinical Biochemistry Human immunodeficiency virus (HIV) ADAMTS13 Protein HIV Infections Disease 030204 cardiovascular system & hematology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine medicine Antiretroviral treatment Humans Acquired Thrombotic Thrombocytopenic Purpura Purpura Thrombotic Thrombocytopenic business.industry Biochemistry (medical) Diagnostic test Purpura Child Preschool 030220 oncology & carcinogenesis medicine.symptom business Sudden onset Rare disease |
| Zdroj: | Laboratory Medicine. |
| ISSN: | 1943-7730 0007-5027 |
| DOI: | 10.1093/labmed/lmy015 |
| Popis: | Acquired thrombotic thrombocytopenic purpura (TTP) is a rare disease in children. Despite advances in diagnosis and treatment, acquired TTP remains a challenging disease due to the lack of a simple diagnostic test and the variable response to plasma exchange. Herein, we describe a case of a 5-year-old of black ethnicity boy who presented with a sudden onset of fatigue and body aches. Laboratory investigations revealed a thrombotic microangiopathic manifestation. TTP was diagnosed, and plasma exchange and corticosteroids were initiated, with an excellent response. Subsequently, reduced disintegrin and metalloprotease with thrombospodin-2-like repeats (ADAMTS-13) activity and human immunodeficiency virus (HIV) were confirmed. Antiretroviral treatment was started as long-term management. At last follow-up, he continues in stable remission. |
| Databáze: | OpenAIRE |
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