Posterior Cervical Brown Fat and CXCL14 Levels in the First Year of Life: Sex Differences and Association With Adiposity
| Autor: | Rubén Cereijo, Cristina Plou, Francis de Zegher, Joan Villarroya, Francesc Villarroya, Aleix Gavaldà-Navarro, Cristina Garcia-Beltran, Abel López-Bermejo, Lourdes Ibáñez, Rita Malpique |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_specialty animal structures Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Adipokine Context (language use) Biochemistry Endocrinology Absorptiometry Photon Sex Factors Adipose Tissue Brown adiposity Internal medicine Brown adipose tissue medicine Humans Longitudinal Studies infancy CXCL14 Adiposity Adiponectin business.industry Insulin Biochemistry (medical) Infant Newborn Infant brown adipose tissue medicine.anatomical_structure Thermography Cohort Female business Thermogenesis Chemokines CXC Neck |
| Zdroj: | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| ISSN: | 0021-972X |
| Popis: | Context Brown adipose tissue (BAT) is particularly abundant in neonates, but its association with measures of adiposity and metabolic health in early infancy is poorly delineated. Besides sustaining nonshivering thermogenesis, BAT secretes brown adipokines that act on systemic metabolism. The chemokine CXCL14 has been identified as a brown adipokine in experimental studies. Objective To determine the relationships among BAT activity, adiposity, and circulating CXCL14 levels in the first year of life in girls and boys. Methods Indices of fat accretion, circulating endocrine–metabolic parameters and serum CXCL14 levels were assessed longitudinally in a cohort of infants at birth and at 4 and 12 months. BAT activity was estimated using infrared thermography only at age 12 months. The main outcome measures were weight and length Z-scores, total and abdominal fat content (by dual X-ray absorptiometry), BAT activity at the posterior cervical and supraclavicular regions, serum levels of glucose, insulin, insulin-like growth factor-I, high-molecular-weight adiponectin, and CXCL14; CXCL14 transcript levels in neonatal BAT and liver. Results Posterior cervical BAT was more active in girls than in boys (P = .02). BAT activity was negatively associated with adiposity parameters only in girls. CXCL14 levels were higher in girls than in boys at age 12 months and correlated positively with the area of active posterior cervical BAT in girls. Neonatal BAT showed high CXCL14 gene expression levels. Conclusion BAT activity and the levels of CXCL14—a potential surrogate of BAT activity—are sex specific in the first year of life. Posterior cervical BAT activity associates negatively with indices of adiposity only in girls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|