Increased platelet distribution width predicts poor prognosis in melanoma patients
| Autor: | Kai Jiang Yu, Zhi Ping Liu, Na Li, Ye Niu, Tiemin Liu, Xiaoyi Huang, Zhiyong Diao, Rui Tao Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Science Kaplan-Meier Estimate Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Blood test Humans Platelet activation Mean platelet volume Neoplasm Metastasis Melanoma Survival analysis Aged Neoplasm Staging Multidisciplinary medicine.diagnostic_test business.industry Proportional hazards model Platelet Count Platelet Distribution Width Hazard ratio Middle Aged Prognosis Confidence interval Tumor Burden 030104 developmental biology ROC Curve 030220 oncology & carcinogenesis Female business Mean Platelet Volume Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Activated platelets promote cancer progression and metastasis. Nevertheless, the prognostic value of platelet indices in melanoma had been rarely reported. The aim of this study was to investigate the predictive significance of platelet indices in melanoma. A total of 220 consecutive patients with melanoma were retrospectively enrolled between January 2009 and December 2009. The relationship between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Of the 220 patients, high platelet distribution width (PDW) levels were observed in 63 (28.6%) patients. Increased PDW was associated with tumor subtype (P |
| Databáze: | OpenAIRE |
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