Effect of Inhaled Nitric Oxide on Cardiovascular Response to Catecholamine in Heart Failure
| Autor: | Masahiko Morihira, Tomoyuki Matsusaka, Hideki Nakamura, Kenjiro Kikuchi, Shunsuke Natori, Takafumi Ohta, Hironobu Matsuhashi, Akira Ido, Yin-Tie Jin, Naoyuki Hasebe, Shiro Tsuji |
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| Rok vydání: | 2000 |
| Předmět: |
Inotrope
Heart disease Hemodynamics Nitric Oxide Ventricular Function Left Nitric oxide Norepinephrine chemistry.chemical_compound Dogs Isoprenaline Administration Inhalation medicine Animals Heart Failure Pharmacology business.industry Isoproterenol medicine.disease Preload medicine.anatomical_structure chemistry Anesthesia Heart failure Vascular resistance Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 36:S55-S60 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-200000006-00012 |
| Popis: | We examined the dose responses to continuous infusion of isoproterenol (ISO) and norepinephrine (NE) in normal (control) and procainamide-induced heart failure dogs with or without inhalation of 70 ppm nitric oxide (NO). Inhaled NO affected neither left ventricular (LV) function nor hemodynamics at baseline in both control and heart failure dogs. There were no significant differences in the responses to ISO and NE with or without inhaled NO in the control. The responses of LV dP/dt to ISO and NE were significantly enhanced in heart failure; however, they were not affected by inhaled NO. In contrast, LV pressure and dimension at end diastole were significantly increased, and pulmonary vascular resistance (PVR) was significantly decreased by inhaled NO during infusion of both ISO and NE in heart failure. In conclusion, the positive inotropic response to cathecholamine is not affected by inhaled NO even in heart failure. Inhaled NO decreases PVR, but potentially increases LV preload in the presence of additional stress of cathecholamine in heart failure. |
| Databáze: | OpenAIRE |
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